There are neurons which rhythmically show self-sustained membrane electrical potential oscillations accompanied by bursts of repetitive impulses. Aims of the present research were: 1) the induction of bursting activity also in neurons non-bursting at rest; 2) the modulation of the discharge pattern in autorhythmic neurons. Two microelectrodes were inserted in Helix pomatia neurons for electrical potential recording and sinusoidal current injection. Responses of silent or regularly beating pacemaker cells to the injected sinusoidal currents are synchronized to the driving cycle and the train of repetitive action potentials is similar to that of bursting cells. The instantaneous firing frequency and the number of action potentials during a burst depend on the amplitude and on the frequency of alternating current. The sinusoidal current produces a sinusoidal modulation of membrane potential accompanied by a relatively small phase shift as expected considering the membrane at rest as represented by an RC parallel network. Repeated cycles of stimulation do not cause identical response patterns, but after some cycles a steady discharge pattern is reached. Adding a DC component (-1÷8 nA) to the stimulating current a potentiation of the action potential amplitude is often obtained at all the tested frequencies (.01÷1 Hz). The increase of stimulation frequency results in a decrease of the discharge frequency value at peak of steady response

DISCHARGE PATTERN MODULATION IN INVERTEBRATE NEURONS / G. Monticelli. ((Intervento presentato al 12. convegno EUROPEAN WINTER CONFERENCE ON BRAIN RESEARCH tenutosi a La Plagne (France) nel 1992.

DISCHARGE PATTERN MODULATION IN INVERTEBRATE NEURONS

G. Monticelli
Primo
1992

Abstract

There are neurons which rhythmically show self-sustained membrane electrical potential oscillations accompanied by bursts of repetitive impulses. Aims of the present research were: 1) the induction of bursting activity also in neurons non-bursting at rest; 2) the modulation of the discharge pattern in autorhythmic neurons. Two microelectrodes were inserted in Helix pomatia neurons for electrical potential recording and sinusoidal current injection. Responses of silent or regularly beating pacemaker cells to the injected sinusoidal currents are synchronized to the driving cycle and the train of repetitive action potentials is similar to that of bursting cells. The instantaneous firing frequency and the number of action potentials during a burst depend on the amplitude and on the frequency of alternating current. The sinusoidal current produces a sinusoidal modulation of membrane potential accompanied by a relatively small phase shift as expected considering the membrane at rest as represented by an RC parallel network. Repeated cycles of stimulation do not cause identical response patterns, but after some cycles a steady discharge pattern is reached. Adding a DC component (-1÷8 nA) to the stimulating current a potentiation of the action potential amplitude is often obtained at all the tested frequencies (.01÷1 Hz). The increase of stimulation frequency results in a decrease of the discharge frequency value at peak of steady response
mar-1992
neuron ; autorhythmic neuron ; bursting activity ; Helix pomatia ; sinusoidal current
Settore BIO/09 - Fisiologia
DISCHARGE PATTERN MODULATION IN INVERTEBRATE NEURONS / G. Monticelli. ((Intervento presentato al 12. convegno EUROPEAN WINTER CONFERENCE ON BRAIN RESEARCH tenutosi a La Plagne (France) nel 1992.
Conference Object
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/66057
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact