L-Carnitine and its esters (acetyl-L-carnitine and propionyl-L-carnitine) at pharmacological doses (1,5 and 100 mM) are absorbed by the rat jejunum by simple diffusion. Partition coefficients of carnitin eesters determined in lipophilic media (diethyl ether/water and olive oil/water) are greater than that of L-carnitine. It would therefore seem that esters diffuse more easily through th elipid component of the intestinal barrier. The transport of acetyl- and propionyl-L-carnitine at pharmacological doses seems to be linearly and positively correlated with K+ transport but not with Na+ transport.
L-carnitine and carnitine ester transport in the rat small intestine / P. Marciani, C. Lindi, A. Marzo, E. Arrigoni Martelli, G. Cardace, G. Esposito. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 23:2(1991), pp. 157-162.
L-carnitine and carnitine ester transport in the rat small intestine
P. Marciani
;C. LindiSecondo
;
1991
Abstract
L-Carnitine and its esters (acetyl-L-carnitine and propionyl-L-carnitine) at pharmacological doses (1,5 and 100 mM) are absorbed by the rat jejunum by simple diffusion. Partition coefficients of carnitin eesters determined in lipophilic media (diethyl ether/water and olive oil/water) are greater than that of L-carnitine. It would therefore seem that esters diffuse more easily through th elipid component of the intestinal barrier. The transport of acetyl- and propionyl-L-carnitine at pharmacological doses seems to be linearly and positively correlated with K+ transport but not with Na+ transport.Pubblicazioni consigliate
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