Very high pre-therapy viral load is a predictor of virological rebound in HIV-1-infected patients starting a modern first-line regimen

Armenia, D.; Di Carlo, D.; Cozzi-Lepri, A.; Calcagno, A.; Borghi, V.; Gori, C.; Bertoli, A.; Gennari, W.; Bellagamba, R.; Castagna, A.; Latini, A.; Pinnetti, C.; Cicalini, S.; Saracino, A.; Lapadula, G.; Rusconi, S.; Castelli, F.; Di Giambenedetto, S.; Andreoni, M.; Di Perri, G.; Antinori, A.; Mussini, C.; Ceccherini-Silberstein, F.; Monforte, A.D.; Perno, C.F.; Santoro, M.M.

doi:10.3851/IMP3309

Pre-cART (combined antiretroviral therapy) plasma viral load >500,000 copies/ml has been associated with a lower probability of achieving virological suppression, while few data about its role on maintenance of virological suppression are available. In this study we aimed to clarify whether high levels of pre-cART viraemia are associated with virological rebound (VR) after virological suppression.

Very high pre-therapy viral load is a predictor of virological rebound in HIV-1-infected patients starting a modern first-line regimen / D. Armenia, D. Di Carlo, A. Cozzi-Lepri, A. Calcagno, V. Borghi, C. Gori, A. Bertoli, W. Gennari, R. Bellagamba, A. Castagna, A. Latini, C. Pinnetti, S. Cicalini, A. Saracino, G. Lapadula, S. Rusconi, F. Castelli, S. Di Giambenedetto, M. Andreoni, G. Di Perri, A. Antinori, C. Mussini, F. Ceccherini-Silberstein, A.D. Monforte, C.F. Perno, M.M. Santoro. - In: ANTIVIRAL THERAPY. - ISSN 1359-6535. - (2019 Apr 12). [Epub ahead of print] [10.3851/IMP3309]