The pathogenesis of bipolar disorder (BD) is to date not entirely clear. Classical genetic research showed that there is a contribution of genetic factors in BD, with high heritability. Twin studies, thanks to the fact that confounding factors as genetic background or family environment are shared, allow etiological inferences. In this work, we selected twin studies, which focus on the relationship between BD, genetic factors and brain structure, evaluated with magnetic resonance imaging. All the studies found differences in brain structure between BD patients and their co-twins, and also in respect to healthy controls. Genetic effects are predominant in white matter, except corpus callosum, while gray matter resulted more influenced by environment, or by the disease itself. All studies found no interactions between BD and shared environment between twins. Twin studies have been demonstrated to be useful in exploring BD pathogenesis and could be extremely effective at discriminating the neural mechanisms underlying BD.

Twin studies for the investigation of the relationships between genetic factors and brain abnormalities in bipolar disorder / L. Squarcina, C. Fagnani, M. Bellani, C.A. Altamura, P. Brambilla. - In: EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES. - ISSN 2045-7960. - 25:6(2016), pp. 515-520. [10.1017/S2045796016000615]

Twin studies for the investigation of the relationships between genetic factors and brain abnormalities in bipolar disorder

L. Squarcina;P. Brambilla
2016

Abstract

The pathogenesis of bipolar disorder (BD) is to date not entirely clear. Classical genetic research showed that there is a contribution of genetic factors in BD, with high heritability. Twin studies, thanks to the fact that confounding factors as genetic background or family environment are shared, allow etiological inferences. In this work, we selected twin studies, which focus on the relationship between BD, genetic factors and brain structure, evaluated with magnetic resonance imaging. All the studies found differences in brain structure between BD patients and their co-twins, and also in respect to healthy controls. Genetic effects are predominant in white matter, except corpus callosum, while gray matter resulted more influenced by environment, or by the disease itself. All studies found no interactions between BD and shared environment between twins. Twin studies have been demonstrated to be useful in exploring BD pathogenesis and could be extremely effective at discriminating the neural mechanisms underlying BD.
bipolar disorder; brain imaging; heritability; magnetic resonance imaging; twin model; Twins; Bipolar Disorder; Brain; Humans; Magnetic Resonance Imaging; Twins, Dizygotic; White Matter; Twin Studies as Topic
Settore MED/25 - Psichiatria
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/660202
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