AIMS: Genetic and environmental factors all interact in the risk of progression of valvular dysfunctions. Previous studies reported a relation between valve diseases and epicardial adipose tissue (EAT) thickness. The aim of this study was to verify the possible relationship between the molecular pattern of EAT related to IL-13 fibrogenic cytokine expression and valve dysfunction. METHODS AND RESULTS: A valvular heart disease (VHD) population was stratified according to their median EAT thickness (7 mm). The molecular expression of IL-13 in EAT is directly related to the molecular expression of genes associated with extracellular matrix (ECM) turnover, macrophage infiltration and promotion of the formation of ectopic calcific nodules involved in aorta coarctation and calcification. CONCLUSION: IL-13 gene expression in altered EAT is directly related to the expression of genes involved in ECM turnover and the formation of ectopic calcific nodules, suggesting measurements of EAT as a stratification risk factor for valve instability in the VHD patients.

Correlational study on altered epicardial adipose tissue as potential stratification risk factor for valve disease progression through IL-13 signaling / E. Vianello, M. Marrocco Trischitta, E. Dozio, F. Bandera, L. Tacchini, E. Canciani, C. Dellavia, G. Schmitz, L. Menicanti, M.M. Corsi Romanelli. - In: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. - ISSN 0022-2828. - 132(2019 Jul), pp. 210-218. [10.1016/j.yjmcc.2019.05.012]

Correlational study on altered epicardial adipose tissue as potential stratification risk factor for valve disease progression through IL-13 signaling

E. Vianello
;
E. Dozio;F. Bandera;L. Tacchini;E. Canciani;C. Dellavia;M.M. Corsi Romanelli
2019-07

Abstract

AIMS: Genetic and environmental factors all interact in the risk of progression of valvular dysfunctions. Previous studies reported a relation between valve diseases and epicardial adipose tissue (EAT) thickness. The aim of this study was to verify the possible relationship between the molecular pattern of EAT related to IL-13 fibrogenic cytokine expression and valve dysfunction. METHODS AND RESULTS: A valvular heart disease (VHD) population was stratified according to their median EAT thickness (7 mm). The molecular expression of IL-13 in EAT is directly related to the molecular expression of genes associated with extracellular matrix (ECM) turnover, macrophage infiltration and promotion of the formation of ectopic calcific nodules involved in aorta coarctation and calcification. CONCLUSION: IL-13 gene expression in altered EAT is directly related to the expression of genes involved in ECM turnover and the formation of ectopic calcific nodules, suggesting measurements of EAT as a stratification risk factor for valve instability in the VHD patients.
Bone morphogenic proteins (BMPs); Epicardial adipose tissue (EAT); IL-13; TGFβ1; Valvular heart disease (VHD); Wnt
Settore BIO/16 - Anatomia Umana
Settore BIO/17 - Istologia
Settore MED/05 - Patologia Clinica
Settore MED/23 - Chirurgia Cardiaca
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/658768
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