The present study aimed to assess the effects of a multimicronutrient food supplement on periodontal clinical parameters and systemic/local inflammatory markers. Thirty patients with severe chronic periodontitis who adhered to the Mediterranean diet (MD) underwent non-surgical therapy and daily took either the micronutrient complex (group-A) or olive oil (group-B) from baseline (T0) to 3 months (T2). Supragingival debridement was performed at T0. One month later (T1), one-stage-full-mouth disinfection was performed. Periodontal clinical parameters were monitored and correlated with serum C-reactive protein (CRP) and salivary matrix metalloproteinase-8/9 (MMPs-8/9) quantified at each time point. Longitudinal analysis revealed that in group-A, the MMP-8/-9 levels were decreased at T2 compared with at T0 (P = 0.013 and P = 0.004, respec-tively) and that the MMP-9 levels were decreased at T1 (P = 0.004). These reductions were not significant in group-B. The CRP levels in both groups did not change over time. No between-group differences were noted for any parameter. The correlation between the full-mouth bleeding score and the MMP-8 level in both groups was significant (P < 0.001). The investigated local and systemic inflammatory parameters were not affected by the tested multimicronutrient supplement in patients who adhered to MD. In conclusion, MMP-8 is useful for assessing the reduction in periodontal inflammation.
Effects of food supplements on periodontal status and local and systemic inflammation after nonoperative periodontal treatment / G. Rasperini, G. Pellegrini, J. Sugai, C. Mauro, S. Fiocchi, P.C. Mora, C. Dellavia. - In: JOURNAL OF ORAL SCIENCE. - ISSN 1343-4934. - 61:2(2019 Jun), pp. 213-220.
|Titolo:||Effects of food supplements on periodontal status and local and systemic inflammation after nonoperative periodontal treatment|
RASPERINI, GIULIO (Corresponding)
|Parole Chiave:||dietary supplements; gingival crevicular fluid; inflammation; metalloproteinase; olive oil; periodontal therapy|
|Settore Scientifico Disciplinare:||Settore BIO/16 - Anatomia Umana|
Settore MED/28 - Malattie Odontostomatologiche
|Data di pubblicazione:||giu-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.2334/josnusd.18-0048|
|Appare nelle tipologie:||01 - Articolo su periodico|