Presented herein is our study of the conformation and reactivity of highly reactive thioglycoside donors. The structural studies have been conducted using NMR spectroscopic and computational methods. The reactivity of these donors has been investigated in bromine-promoted glycosylations of aliphatic and sugar alcohols. Swift reaction times, high yields, and respectable 1,2-cis stereoselectivity were observed in a majority of these glycosylations.
Bromine-promoted glycosidation of conformationally superarmed thioglycosides / M. Panza, M. Civera, J.P. Yasomanee, L. Belvisi, A.V. Demchenko. - In: CHEMISTRY. - ISSN 1521-3765. - 25(2019), pp. 11831-11836. [10.1002/chem.201901969]
Bromine-promoted glycosidation of conformationally superarmed thioglycosides
M. CiveraSecondo
;L. Belvisi
Penultimo
;
2019
Abstract
Presented herein is our study of the conformation and reactivity of highly reactive thioglycoside donors. The structural studies have been conducted using NMR spectroscopic and computational methods. The reactivity of these donors has been investigated in bromine-promoted glycosylations of aliphatic and sugar alcohols. Swift reaction times, high yields, and respectable 1,2-cis stereoselectivity were observed in a majority of these glycosylations.
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