ATR (Ataxia Telangiectasia and Rad3-related) is a member of the Phosphatidylinositol 3-kinase-related kinases (PIKKs) family, amongst six other vertebrate proteins known so far. ATR is indispensable for cell survival and its essential role is in sensing DNA damage and initiating appropriate repair responses. In this review we highlight emerging and recent observations connecting ATR to alternative roles in controlling the nuclear envelope, nucleolus, centrosome and other organelles in response to both internal and external stress conditions. We propose that ATR functions control cell plasticity by sensing structural deformations of different cellular components, including DNA and initiating appropriate repair responses, most of which are yet to be understood completely.
ATR-mediated regulation of nuclear and cellular plasticity / G.R. Kidiyoor, A. Kumar, M. Foiani. - In: DNA REPAIR. - ISSN 1568-7864. - 44(2016), pp. 143-150.
|Titolo:||ATR-mediated regulation of nuclear and cellular plasticity|
KIDIYOOR, GURURAJ RAO (Primo)
FOIANI, MARCO (Ultimo) (Corresponding)
|Parole Chiave:||ATR; Cellular plasticity; Centrosome; Nuclear envelope; Nucleolus; PIKK; Ataxia Telangiectasia Mutated Proteins; Cell Nucleolus; Centrosome; DNA; DNA Damage; Eukaryotic Cells; Humans; Nuclear Envelope; Cell Plasticity; DNA Repair; Biochemistry; Molecular Biology; Cell Biology|
|Settore Scientifico Disciplinare:||Settore BIO/11 - Biologia Molecolare|
|Data di pubblicazione:||2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.dnarep.2016.05.020|
|Appare nelle tipologie:||01 - Articolo su periodico|