Background: In the last decades, there has been increasing interest in investigating the role of the vermis in bipolar disorder (BD), especially because of its involvement in cognitive processes. The main aims of this study were to explore the integrity of the vermis and elucidate the role of demographic and clinical variables on vermis volumes in BD patients, stratified according to gender. Methods: T1-weighted images were obtained for 38 BD patients and 38 healthy controls using a 1.5-T MRI scanner. Images were analyzed with a PC workstation with BRAINS2 software on a Linux system. Anatomical regions were traced manually from a blinded operator, with respect to subject identity and other clinical variables. Results: The direct comparison between the 2 groups showed no significant gray matter differences in vermis volumes. Interestingly, vermis volumes were significantly inversely associated with chronological age and age of BD onset, particularly in male subjects. Conclusions: Our study provides evidence of the impact of aging on the vermis in BD, potentially related to earlier and faster gender-related neurodegenerative phenomena occurring during the progression of the disease.

Potential Gender-Related Aging Processes Occur Earlier and Faster in the Vermis of Patients with Bipolar Disorder: An MRI Study / M. Serati, G. Delvecchio, G. Orsenigo, C. Perlini, M. Barillari, M. Ruggeri, A.C. Altamura, M. Bellani, P. Brambilla. - In: NEUROPSYCHOBIOLOGY. - ISSN 0302-282X. - 75:1(2017 Nov), pp. 32-38. [10.1159/000477967]

Potential Gender-Related Aging Processes Occur Earlier and Faster in the Vermis of Patients with Bipolar Disorder: An MRI Study

M. Serati
Primo
;
G. Delvecchio
Secondo
;
G. Orsenigo;A.C. Altamura;P. Brambilla
Ultimo
2017

Abstract

Background: In the last decades, there has been increasing interest in investigating the role of the vermis in bipolar disorder (BD), especially because of its involvement in cognitive processes. The main aims of this study were to explore the integrity of the vermis and elucidate the role of demographic and clinical variables on vermis volumes in BD patients, stratified according to gender. Methods: T1-weighted images were obtained for 38 BD patients and 38 healthy controls using a 1.5-T MRI scanner. Images were analyzed with a PC workstation with BRAINS2 software on a Linux system. Anatomical regions were traced manually from a blinded operator, with respect to subject identity and other clinical variables. Results: The direct comparison between the 2 groups showed no significant gray matter differences in vermis volumes. Interestingly, vermis volumes were significantly inversely associated with chronological age and age of BD onset, particularly in male subjects. Conclusions: Our study provides evidence of the impact of aging on the vermis in BD, potentially related to earlier and faster gender-related neurodegenerative phenomena occurring during the progression of the disease.
Bipolar disorder; Cerebellum; Magnetic resonance imaging; Vermis; Adult; Bipolar Disorder; Cerebral Cortex; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Psychiatric Status Rating Scales; Statistics as Topic; Aging; Disease Progression; Magnetic Resonance Imaging; Sex Characteristics
Settore MED/25 - Psichiatria
Article (author)
File in questo prodotto:
File Dimensione Formato  
serati2017.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 153.15 kB
Formato Adobe PDF
153.15 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/657561
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 1
social impact