Angiogenesis, the growth of new blood vessels from preexisting ones, is a fundamental process for organ development, exercise-induced muscle growth, and wound healing, but is also associated with different diseases such as cancer and neovascular eye disease. Accordingly, elucidating the molecular and cellular mechanisms of angiogenesis has the potential to identify new therapeutic targets to stimulate new vessel formation in ischemic tissues or inhibit pathological vessel growth in disease. This chapter describes the mouse embryo hindbrain and postnatal retina as models to study physiological angiogenesis and provides detailed protocols for tissue dissection, sample staining, and analysis.
The embryonic mouse hindbrain and postnatal retina as in vivo models to study angiogenesis / A. Fantin, C. Ruhrberg (METHODS IN MOLECULAR BIOLOGY). - In: VEGF Signalling : Methods and Protocols / [a cura di] L. Fiedler. - [s.l] : Springer, 2015. - ISBN 9781493929160. - pp. 177-188 [10.1007/978-1-4939-2917-7_13]
The embryonic mouse hindbrain and postnatal retina as in vivo models to study angiogenesis
A. Fantin
Primo
;
2015
Abstract
Angiogenesis, the growth of new blood vessels from preexisting ones, is a fundamental process for organ development, exercise-induced muscle growth, and wound healing, but is also associated with different diseases such as cancer and neovascular eye disease. Accordingly, elucidating the molecular and cellular mechanisms of angiogenesis has the potential to identify new therapeutic targets to stimulate new vessel formation in ischemic tissues or inhibit pathological vessel growth in disease. This chapter describes the mouse embryo hindbrain and postnatal retina as models to study physiological angiogenesis and provides detailed protocols for tissue dissection, sample staining, and analysis.File | Dimensione | Formato | |
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