Background: Paclitaxel is a plant product highly active in numerous cancers, but anaphylactic-like hypersensitivity reactions with it have been reported in about 28% of patients receiving the drug. Thirty to sixty minutes are needed to give a standard premedication with steroids and diphenhydramine, leading to patients and nurses' discomfort and stealing time from other infusional treatments. Patients and methods: Eighty-nine patients with advanced NSCLC never pre-treated with taxanes, received paclitaxel followed by gemcitabine on days 1, 8, 15 q4wks. Premedication consisted of prednisone 25 mg/os on day 0 and hydrocortisone plus clorfenamina maleato given intravenous on day 1 by a 15 min infusion immediately before paclitaxel administration. Results: Hypersensitivity reactions occurred in 3/341 (0.8%) cycles. In all three cases we observed severe dyspnoea and bronchospasm, that required treatment discontinuation but one was probably due to gemcitabine and another had a protracting time after premedication. Conclusions: A 15-min premedication infusion administered immediately before paclitaxel appeared to be highly effective in patients treated with 1 h-infusion paclitaxel.
A 15-min premedication for 1-h paclitaxel infusion: optimizing patients' care / A. Milani, T. De Pas, C. Noberasco, C. Mcdonnell, L. Libutti, I. Limardi, C. Zencovich, S. Boselli, M. Bianchi, F. de Braud. - In: LUNG CANCER. - ISSN 0169-5002. - 58:2(2007), pp. 300-301.
|Titolo:||A 15-min premedication for 1-h paclitaxel infusion: optimizing patients' care|
|Parole Chiave:||NSCLC; paclitaxel; hypersensitivity reaction; weekly administration; premedication; drug administration time|
|Settore Scientifico Disciplinare:||Settore MED/06 - Oncologia Medica|
|Data di pubblicazione:||2007|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.lungcan.2007.08.009|
|Appare nelle tipologie:||01 - Articolo su periodico|