The effects of atherogenic lipoproteins on the release of tissue plasminogen activator inhibitor (PAI-1) by endothelial cells were evaluated. Incubation of cultured human umbilical vein endothelial cells (EC) with very low density (VLDL) and low density (LDL) lipoproteins induced a two fold increase of PAI-1 release by EC. Similarly acetylated LDL (acetyl-LDL) stimulated PAI-1 release by EC, whereas oxidized LDL (ox-LDL) reduced it. It is concluded that atherogenic lipoproteins profoundly influence the capacity of EC to release proteins with thrombogenic properties.
Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells / L. Mussoni, P. Madema, M. Camera, F. Bemini, L. Sironi, M. Sirtori, E. Tremoli. - In: FIBRINOLYSIS. - ISSN 0268-9499. - 4:suppl. 2(1990), pp. 79-81.
|Titolo:||Atherogenic lipoproteins and release of plasminogen activator inhibitor-1 (PAI-1) by endothelial cells|
|Parole Chiave:||Atherogenic lipoproteins; Endothelial cells; Plasminogen activator inhibitor|
|Settore Scientifico Disciplinare:||Settore BIO/15 - Biologia Farmaceutica|
|Data di pubblicazione:||1990|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0268-9499(90)90367-S|
|Appare nelle tipologie:||01 - Articolo su periodico|