The reaction of 3',5'-di-O-acetylthymidine with [Pt(PPh3)(4)] and KCl yielded a platinum(II) complex where the platinum is co-ordinated to the nucleobase through the N3 atom. In a similar reaction 1-methylthymine (1-MeThy) furnished the complex cis-[PtCl(1-MeThy)(PPh3)(2)], whose structure was determined by spectroscopic data and single crystal X-ray diffraction. When 1-MeThy was treated with [Pt(PPh3)(4)] in the absence of chloride ions the complex trans-[Pt(OH)(1-MeThy)(PPh3)(2)] was obtained.
Synthesis of platinum(II) complexes of thymidine and 1-methylthymine (1-MeThy); crystal structure of cis-[PtCl(1-MeThy)-(PPh3)2] / L. De Napoli, R. Iacovino, A. Messere, D. Montesarchio, G. Piccialli, A. Romanelli, F. Ruffo, M. Saviano. - In: JOURNAL OF THE CHEMICAL SOCIETY DALTON TRANSACTIONS. - ISSN 0300-9246. - 1999:12(1999), pp. 1945-1949.
Synthesis of platinum(II) complexes of thymidine and 1-methylthymine (1-MeThy); crystal structure of cis-[PtCl(1-MeThy)-(PPh3)2]
A. Romanelli;
1999
Abstract
The reaction of 3',5'-di-O-acetylthymidine with [Pt(PPh3)(4)] and KCl yielded a platinum(II) complex where the platinum is co-ordinated to the nucleobase through the N3 atom. In a similar reaction 1-methylthymine (1-MeThy) furnished the complex cis-[PtCl(1-MeThy)(PPh3)(2)], whose structure was determined by spectroscopic data and single crystal X-ray diffraction. When 1-MeThy was treated with [Pt(PPh3)(4)] in the absence of chloride ions the complex trans-[Pt(OH)(1-MeThy)(PPh3)(2)] was obtained.
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