Antibacterial treatment is an essential issue in many diverse fields, from medical device treatments (for example prostheses coating) to food preservation. However, there is a need of novel and light-weight materials with high antibacterial efficiency (preferably due to the physical activation). Utilization of photo-thermally active nanoparticles can lead to novel and re-usable materials that can be remotely activated on-demand to thermally eradicate bacteria and mitigate biofilm formation, therefore meeting the above challenge. In this study polyvinyl alcohol (PVA) hydrogel films containing non-toxic and highly photo-thermally active Prussian blue (PB) nanoparticles were fabricated. The confocal microscopy studies indicated a uniform nanoparticle distribution and a low degree of aggregation. Upon near-infrared (NIR; 700 and 800 nm) light irradiation of PVA-PB films, the local temperature increases rapidly and reaches a plateau (up to ΔT ≅ 78 °C), within ≈6-10 s under relatively low laser intensities, I ≅ 0.3 W cm-2. The high and localized increase of temperature on the fabricated films resulted in an efficient antibacterial effect on Pseudomonas aeruginosa (P. aeruginosa) bacteria. In addition, the localized photo-thermal effect was also sufficient to substantially mitigate biofilms growth.
|Titolo:||Novel photo-thermally active polyvinyl alcohol-Prussian blue nanoparticles hydrogel films capable of eradicating bacteria and mitigating biofilms|
|Parole Chiave:||Anti-Bacterial Agents; Biofilms; Ferrocyanides; Hot Temperature; Lasers; Low-Level Light Therapy; Nanoparticles; Phototherapy; Polyvinyl Alcohol; Pseudomonas aeruginosa|
|Settore Scientifico Disciplinare:||Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)|
Settore BIO/19 - Microbiologia Generale
|Data di pubblicazione:||26-apr-2019|
|Digital Object Identifier (DOI):||10.1088/1361-6528/ab15f9|
|Appare nelle tipologie:||01 - Articolo su periodico|