Molecules able to interfere in miRNA genesis and function are potent tools to unravel maturation and processing pathways. Antisense oligonucleotides or analogs are actually employed for the inhibition of miRNA function. Here we illustrate how Peptide Nucleic Acids oligomers targeting pre-miRNA are exploited to inhibit miRNA maturation.
Inhibition of miRNA maturation by peptide nucleic acids / C. Avitabile, E. Fabbri, N. Bianchi, R. Gambari, A. Romanelli (METHODS IN MOLECULAR BIOLOGY). - In: miRNA maturation : methods and protocols / [a cura di] C. Arenz. - Prima edizione. - New York : Humana Press, 2014. - ISBN 9781627037020. - pp. 157-164
Inhibition of miRNA maturation by peptide nucleic acids
A. Romanelli
2014
Abstract
Molecules able to interfere in miRNA genesis and function are potent tools to unravel maturation and processing pathways. Antisense oligonucleotides or analogs are actually employed for the inhibition of miRNA function. Here we illustrate how Peptide Nucleic Acids oligomers targeting pre-miRNA are exploited to inhibit miRNA maturation.
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