b-Hairpin peptides were conformationally stabilized through a 1,4 disubstituted 1,2,3-triazole interstrand linkage. A NMR conformational analysis revealed that the b-hairpin content depends on the number and position of substituent methylene units of the 1,2,3-triazole ring. These results will allow the design of metabolically stable peptidomimetic analogs of bioactive b-hairpin peptides.
β-Hairpin stabilization through an interstrand triazole bridge / V. Celentano, D. Diana, L. De Rosa, A. Romanelli, R. Fattorusso, L.D. D'Andrea. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 48:5(2012), pp. 762-764.
β-Hairpin stabilization through an interstrand triazole bridge
A. Romanelli;
2012
Abstract
b-Hairpin peptides were conformationally stabilized through a 1,4 disubstituted 1,2,3-triazole interstrand linkage. A NMR conformational analysis revealed that the b-hairpin content depends on the number and position of substituent methylene units of the 1,2,3-triazole ring. These results will allow the design of metabolically stable peptidomimetic analogs of bioactive b-hairpin peptides.
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