Recent studies on Andean children indicate a prevalence of dyslipidemia and hypertension compared to dwellers at lower altitudes, suggesting that despite similar food intake and daily activities, they undergo different metabolic adaptations. In the present study, the sphingolipid pattern was investigated in serum of 7 underweight (UW), 30 normal weight (NW), 13 overweight (OW), and 9 obese (O) Andean children by liquid chromatography-mass spectrometry (LC-MS). Results indicate that levels of Ceramides (Cers) and sphingomyelins (SMs) correlate positively with biochemical parameters (except for Cers and Vitamin D, which correlate negatively), whereas sphingosine-1-phosphate (S1P) correlates negatively. Correlation results and LC-MS data identify the axis high density lipoprotein-cholesterol (HDL-C), Cers, and S1P as related to hypoxia adaptation. Specifically UW children are characterized by increased levels of S1P compared to O and lower levels of Cers compared to NW children. Furthermore, O children show lower levels of S1P and similar levels of Cers and SMs as NW. In conclusion, our results indicate that S1P is the primary target of hypoxia adaptation in Andean children, and its levels are associated with hypoxia tolerance. Furthermore, S1P can act as marker of increased risk of metabolic syndrome and cardiac dysfunction in young Andeans living at altitude.
Regulation of Serum Sphingolipids in Andean Children Born and Living at High Altitude (3775 m) / P. Barbacini, J. Casas, E. Torretta, D. Capitanio, G. Maccallini, V. Hirschler, C. Gelfi. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 20:11(2019 Jun 11). ((Intervento presentato al convegno Adaptation to Hypoxia: A Chimera?".
|Titolo:||Regulation of Serum Sphingolipids in Andean Children Born and Living at High Altitude (3775 m)|
BARBACINI, PIETRO (Primo)
GELFI, CECILIA (Ultimo) (Corresponding)
|Parole Chiave:||LC-MS/MS; ceramides; dyslipidemia; high-altitude hypoxia; sphingolipids; sphingomyelins; sphingosine-1-phosphate|
|Settore Scientifico Disciplinare:||Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica|
|Data di pubblicazione:||11-giu-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/ijms20112835|
|Appare nelle tipologie:||01 - Articolo su periodico|