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AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishOBJECTIVE: To evaluate the effects of antiretroviral treatment (ART) for mother-to-child transmission of HIV and infant/maternal characteristics on total lymphocytes (TLC) and lymphocyte subsets in uninfected children of HIV-1-infected mothers. DESIGN: The European Collaborative Study followed 1663 uninfected children from birth until at least 8 years of age using a standard protocol. METHODS: Smoothers (running medians) illustrated patterns of immune markers over age by ART exposure and race. Associations between lymphocyte parameters and maternal/infant characteristics were quantified in linear regression analyses using z-scores obtained after modelling log10-transformed TLC, CD4 and CD8 cell counts using the LMS method. Cox proportional hazard models assessed time to TLC, CD4 and CD8 cell counts below the defined cut-off. Covariates included prematurity, gender, race, drug withdrawal and ART exposure. RESULTS: Overall, black children had lower TLC, CD4 and CD8 cell counts than white children, and an increased risk of TLC, CD4 and CD8 cell counts below the cut-off. ART exposure was associated with TLC levels (but not with TLC below the cut-off for lymphopenia), with reduced CD4 cell counts in the first year of life, and with reduced CD8 cell counts until at least 8 years of age. Duration and intensity of ART exposure was associated with TLC levels. CONCLUSION: The effect of ART exposure in fetal and early life on TLC and CD8 cell counts was prolonged until at least 8 years. These results add to the growing list of adverse effects associated with ART used as prevention of mother-to-child transmission of HIV.
| Titolo: | Maternal and infant factors and lymphocyte, CD4 and CD8 cell counts in uninfected children of HIV-1 infected mothers |
| Autori: | FERRAZZI, ENRICO MARIO (Penultimo) |
| Parole Chiave: | Antiretroviral treatment; Gender; Haematopoiesis; Race; Uninfected children |
| Settore Scientifico Disciplinare: | Settore MED/40 - Ginecologia e Ostetricia |
| Data di pubblicazione: | 2005 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | 10.1097/01.aids.0000174454.63250.22 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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