Adaptation to low oxygen tension or hypoxia is a critical event in development and tissue homeostasis. Studies by us and others have shown that the fetal growth plate is an avascular tissue with a gradient of oxygenation, and the transcription factor hypoxia-inducible factor-1 alpha (HIF-1 alpha) is essential for its development. In this brief review, we will summarize our current understanding of the role of HIF-1 alpha in fetal growth plate development, and we will discuss yet unanswered questions in the field of hypoxia and endochondral bone formation.

HIF-1α and growth plate development: what we really know / E. Schipani, L. Mangiavini, C. Merceron. - In: BONEKEY REPORTS. - ISSN 2047-6396. - 4:(2015 Aug 12). [10.1038/bonekey.2015.99]

HIF-1α and growth plate development: what we really know

L. Mangiavini
Secondo
;
2015-08-12

Abstract

Adaptation to low oxygen tension or hypoxia is a critical event in development and tissue homeostasis. Studies by us and others have shown that the fetal growth plate is an avascular tissue with a gradient of oxygenation, and the transcription factor hypoxia-inducible factor-1 alpha (HIF-1 alpha) is essential for its development. In this brief review, we will summarize our current understanding of the role of HIF-1 alpha in fetal growth plate development, and we will discuss yet unanswered questions in the field of hypoxia and endochondral bone formation.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/651145
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