Adaptation to low oxygen tension or hypoxia is a critical event in development and tissue homeostasis. Studies by us and others have shown that the fetal growth plate is an avascular tissue with a gradient of oxygenation, and the transcription factor hypoxia-inducible factor-1 alpha (HIF-1 alpha) is essential for its development. In this brief review, we will summarize our current understanding of the role of HIF-1 alpha in fetal growth plate development, and we will discuss yet unanswered questions in the field of hypoxia and endochondral bone formation.
HIF-1α and growth plate development: what we really know / E. Schipani, L. Mangiavini, C. Merceron. - In: BONEKEY REPORTS. - ISSN 2047-6396. - 4(2015 Aug 12).
|Titolo:||HIF-1α and growth plate development: what we really know|
MANGIAVINI, LAURA (Secondo)
|Settore Scientifico Disciplinare:||Settore MED/33 - Malattie Apparato Locomotore|
|Data di pubblicazione:||12-ago-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/bonekey.2015.99|
|Appare nelle tipologie:||01 - Articolo su periodico|