Background: Keloidal fibrosarcoma (KFS) is an uncommon type of fibrosarcoma, which is characterized by the deposition of aggregatesof hyalinized (“keloid”) collagen. Marked cellular atypia, higher mitotic rate, infiltrative growth, and regions of high cellularity, distinguish KFS from the benign counterpart (keloidal fibroma). Objectives: Review the cytologic, histologic, and immunohisto- chemical features of KFS, and report two new cases of canine KFS. Case descriptions: Two otherwise healthy dogs, were presented to clinicians for the onset a single, subcutaneous, firm, and hairy nodule. The clinical investigation included fine needle aspirate of the nodule, followed by excisional biopsy. Cytologic and histologic sam- ples were routinely stained. Immunohistochemistry for vimentin, a‐ SMA, and CD18 was also performed. Smears were moderately cellu- lar, with the prevalence of atypical large spindle cells, individualized or in small groups. Scattered mast cells and histiocytes, admixed with hyalinized collagen fragments were also present. Cytologic findings were consistent with a KFS, nevertheless, a keloidal fibroma and mast cell tumor could not be ruled‐out based on the cytomorphology only. Histologically, the neoplasm was infiltrative, with areas of hypercellularity. Furthermore, neoplastic cells were vimentin positive and a‐SMA negative, while admixed histiocytes expressed CD18. Based on histology and immunohistochemistry, a final diagnosis of KSF was granted. Conclusions: Cytologic detection of large bundles of hyalinized collagen admixed with large spindle cells are a distinctive finding of keloidal tumors of dogs. Neoplastic cells in canine keloidal tumors are vimentin positive and smooth muscle actin negative and are interpreted to be fibroblasts.
Canine keloidal fibrosarcoma: Two case reports and review of the literature / G. Ghisleni, M. Attini, M. Gambini, M. Tecilla, S. Selenia Cardinelli, S. Melzi, M. Caniatti. - In: VETERINARY CLINICAL PATHOLOGY. - ISSN 0275-6382. - 48:1(2019), pp. 198-199. ((Intervento presentato al 20. convegno European Society of Veterinary Clinical Pathology (ESVCP)/European College of Veterinary Clinical Pathology (ECVCP) tenutosi a Athen nel 2018.
|Titolo:||Canine keloidal fibrosarcoma: Two case reports and review of the literature|
|Settore Scientifico Disciplinare:||Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria|
|Data di pubblicazione:||2019|
|Appare nelle tipologie:||01 - Articolo su periodico|