Background: The use of multiparametric magnetic resonance imaging (mpMRI) in the setting of patients under active surveillance (AS) is promising. In this systematic-review we aimed to analyse the role of mpMRI in patients under AS. Methods: A comprehensive literature research for English-language original and review articles, recently published, was carried out using Medline, Scopus and Web of sciences databases until 30 October 2017. The following MeSH terms were used: 'active surveillance', 'prostate cancer', 'multiparametric magnetic resonance imaging'. A diagnostic meta-analysis was performed for 3.0 T mpMRI in predicting disease re-classification. Results: In total, 226 studies were selected after research and after removal of duplicates. After analysis on inclusion criteria, 43 studies were identified as eligible for this systematic review with a total of 6,605 patients. The timing of MRI during follow-up of AS differed from all studies like criteria for inclusion in the AS protocol. Overall, there was a low risk of bias across all studies. The diagnostic meta-analysis for 1.5 tesla showed a sensitivity of 0.60, negative predictive value (NPV) of 0.75 and a hierarchical summary receiving operating curve (HSROC) of 0.74 while for 3.0 tesla mpMRI a sensitivity of 0.81, a NPV of 0.78 and a HSROC of 0.83. Conclusions: Overall, the available evidence suggests that both 1.5 or 3.0 Tesla mpMRI are a valid tool to monitor progression during AS follow-up, showing good accuracy capabilities in detecting PCa re-classification. However, the modality to better define what means 'disease progression' on mpMRI must be further evaluated.
Role of multiparametric magnetic resonance imaging for patients under active surveillance for prostate cancer : a systematic review with diagnostic meta-analysis / F. Cantiello, G.I. Russo, S. Kaufmann, G. Cacciamani, F. Crocerossa, M. Ferro, O. De Cobelli, W. Artibani, S. Cimino, G. Morgia, R. Damiano, K. Nikolaou, N. Kröger, A. Stenzl, J. Bedke, S. Kruck. - In: PROSTATE CANCER AND PROSTATIC DISEASES. - ISSN 1365-7852. - 22:2(2019), pp. 206-220.
|Titolo:||Role of multiparametric magnetic resonance imaging for patients under active surveillance for prostate cancer : a systematic review with diagnostic meta-analysis|
|Parole Chiave:||Oncology; Urology; Cancer Research|
|Settore Scientifico Disciplinare:||Settore MED/24 - Urologia|
|Data di pubblicazione:||2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/s41391-018-0113-2|
|Appare nelle tipologie:||01 - Articolo su periodico|