Burns and chronic wounds, often related to chronic diseases (as diabetes and cancer), are challenging lesions, difficult to heal. The prompt and full reconstitution of a functional skin is at the basis of the development of biopolymer-based scaffolds, representing a 3D substrate mimicking the dermal extracellular matrix. Aim of the work was to develop scaffolds intended for skin regeneration, according to: fabrication by electrospinning from aqueous polysaccharide solutions; prompt and easy treatment to obtain scaffolds insoluble in aqueous fluids; best performance in supporting wound healing. Three formulations were tested, based on chitosan (CH)and pullulan (P), associated with glycosaminoglycans (chondroitin sulfate - CS or hyaluronic acid – HA). A multidisciplinary approach has been used: chemico-physical characterization and preclinical evaluation allowed to obtain integrated information. This supports that CS gives distinctive properties and optimal features to the scaffold structure for promoting cell proliferation leading tissue reparation towards a complete skin restore.

Chitosan/glycosaminoglycan scaffolds for skin reparation / G. Sandri, S. Rossi, M.C. Bonferoni, D. Miele, A. Faccendini, E. Del Favero, E. Di Cola, A. Icaro Cornaglia, C. Boselli, T. Luxbacher, L. Malavasi, L. Cantu’, F. Ferrari. - In: CARBOHYDRATE POLYMERS. - ISSN 0144-8617. - 220(2019), pp. 219-227. [10.1016/j.carbpol.2019.05.069]

Chitosan/glycosaminoglycan scaffolds for skin reparation

Del Favero, Elena;Di Cola, Emanuela;Cantu’, Laura;
2019

Abstract

Burns and chronic wounds, often related to chronic diseases (as diabetes and cancer), are challenging lesions, difficult to heal. The prompt and full reconstitution of a functional skin is at the basis of the development of biopolymer-based scaffolds, representing a 3D substrate mimicking the dermal extracellular matrix. Aim of the work was to develop scaffolds intended for skin regeneration, according to: fabrication by electrospinning from aqueous polysaccharide solutions; prompt and easy treatment to obtain scaffolds insoluble in aqueous fluids; best performance in supporting wound healing. Three formulations were tested, based on chitosan (CH)and pullulan (P), associated with glycosaminoglycans (chondroitin sulfate - CS or hyaluronic acid – HA). A multidisciplinary approach has been used: chemico-physical characterization and preclinical evaluation allowed to obtain integrated information. This supports that CS gives distinctive properties and optimal features to the scaffold structure for promoting cell proliferation leading tissue reparation towards a complete skin restore.
Chitosan; Chronic wound and burn healing; Electrospinning; Glycosaminoglycans; In vitro and In vivo models
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
CARBOHYDRATE POLYMERS
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0144861719305855-main.pdf

non disponibili

Tipologia: Publisher's version/PDF
Dimensione 8.28 MB
Formato Adobe PDF
8.28 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Manuscript_accepted.pdf

accesso aperto

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 3.38 MB
Formato Adobe PDF
3.38 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/647860
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 28
social impact