During my PhD courses I focused attention on the applications of mass spectrometry in lipidomic studies. I applied mass spectrometry in several experimental models to try to observe differences in selected metabolites affected by a particular pathology. The first project performed in experimental model of impaird lipogenesis highlighted a cross talk between altered fatty acid synthesis and neuroactive steroid levels. The second project, mass spectrometry application allows to understand he effect of short-term diabetes on cholesterol metabolism. In the last project lipidomic pattern was investigated in experimental model of SCA38. Results obtained highlighted as elovl5 mutation affect phospholipids profile.

Lipids and Mass Spectrometry Application / R. Spezzano ; tutor: D. Caruso ; coordinator: A. Prinetti. - : . DIPARTIMENTO DI SCIENZE FARMACOLOGICHE E BIOMOLECOLARI, 2019 May 30. ((31. ciclo, Anno Accademico 2018. [10.13130/spezzano-roberto_phd2019-05-30].

Lipids and Mass Spectrometry Application

R. Spezzano
2019-05-30

Abstract

During my PhD courses I focused attention on the applications of mass spectrometry in lipidomic studies. I applied mass spectrometry in several experimental models to try to observe differences in selected metabolites affected by a particular pathology. The first project performed in experimental model of impaird lipogenesis highlighted a cross talk between altered fatty acid synthesis and neuroactive steroid levels. The second project, mass spectrometry application allows to understand he effect of short-term diabetes on cholesterol metabolism. In the last project lipidomic pattern was investigated in experimental model of SCA38. Results obtained highlighted as elovl5 mutation affect phospholipids profile.
CARUSO, DONATELLA
PRINETTI, ALESSANDRO ENNIO GIUSEPPE
Lipidomic; Mass spectrometry
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
Lipids and Mass Spectrometry Application / R. Spezzano ; tutor: D. Caruso ; coordinator: A. Prinetti. - : . DIPARTIMENTO DI SCIENZE FARMACOLOGICHE E BIOMOLECOLARI, 2019 May 30. ((31. ciclo, Anno Accademico 2018. [10.13130/spezzano-roberto_phd2019-05-30].
Doctoral Thesis
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/647470
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