Objectives To compare the Vasculitis Damage Index (VDI) with the Combined Damage Assessment Index (CDA) as measures of damage from vasculitis. Methods A total of 283 patients with vasculitis from 11 European centres were evaluated in a cross-sectional study using the VDI and CDA. Results Wegener's granulomatosis (58.4%) and microscopic polyangiitis (11.0%) were the most common diagnoses. Agreement between VDI and CDA scores (Spearman's correlation) was 0.90 (95% CI 0.87 to 0.92). There was good correlation between individual comparably evaluated organ systems (Spearman's correlation 0.70-0.94). Interobserver reliability (assessed by intraclass correlation coefficient (ICC)) was 0.94 (95% CI 0.89 to 0.98) for VDI and 0.78 (95% CI 0.63 to 0.93) for CDA. Intraobserver reliability was 0.92 (95% CI 0.83 to 1.00) for VDI and 0.87 (95% CI 0.75 to 1.00) for CDA. A total of 13 items were not used in the VDI compared to 23 in the CDA. Observers agreed that the CDA covered the full spectrum of damage attributable to vasculitis but was more time consuming and thus possibly less feasible for clinical and research purposes. Conclusions The VDI and CDA capture reliable data on damage among patients with vasculitis. The CDA captures more detail but is more complex and less practical than the VDI. Further evolution of damage assessment in vasculitis is likely to include key elements from both instruments.

Measurement of damage in systemic vasculitis: a comparison of the Vasculitis Damage Index with the Combined Damage Assessment Index / R. Suppiah, O. Flossman, C. Mukhtyar, F. Alberici, B. Baslund, D. Brown, N. Hasan, J. Holle, Z. Hruskova, D. Jayne, A. Judge, M.A. Little, P.A. Merkel, A. Palmisano, P. Seo, C. Stegeman, V. Tesar, A. Vaglio, K. Westman, R. Luqmani. - In: ANNALS OF THE RHEUMATIC DISEASES. - ISSN 0003-4967. - 70:1(2011 Jan), pp. 80-85. [10.1136/ard.2009.122952]

Measurement of damage in systemic vasculitis: a comparison of the Vasculitis Damage Index with the Combined Damage Assessment Index

F. Alberici;
2011

Abstract

Objectives To compare the Vasculitis Damage Index (VDI) with the Combined Damage Assessment Index (CDA) as measures of damage from vasculitis. Methods A total of 283 patients with vasculitis from 11 European centres were evaluated in a cross-sectional study using the VDI and CDA. Results Wegener's granulomatosis (58.4%) and microscopic polyangiitis (11.0%) were the most common diagnoses. Agreement between VDI and CDA scores (Spearman's correlation) was 0.90 (95% CI 0.87 to 0.92). There was good correlation between individual comparably evaluated organ systems (Spearman's correlation 0.70-0.94). Interobserver reliability (assessed by intraclass correlation coefficient (ICC)) was 0.94 (95% CI 0.89 to 0.98) for VDI and 0.78 (95% CI 0.63 to 0.93) for CDA. Intraobserver reliability was 0.92 (95% CI 0.83 to 1.00) for VDI and 0.87 (95% CI 0.75 to 1.00) for CDA. A total of 13 items were not used in the VDI compared to 23 in the CDA. Observers agreed that the CDA covered the full spectrum of damage attributable to vasculitis but was more time consuming and thus possibly less feasible for clinical and research purposes. Conclusions The VDI and CDA capture reliable data on damage among patients with vasculitis. The CDA captures more detail but is more complex and less practical than the VDI. Further evolution of damage assessment in vasculitis is likely to include key elements from both instruments.
Antibody-associated vasculitis; term-follow-up; wegeners-granulomatosis; randomized-trial; microscopic polyangiitis; polyarteritis-nodosa; outcome measures; plasma-exchange; cyclophosphamide; therapy
Settore MED/14 - Nefrologia
gen-2011
Article (author)
File in questo prodotto:
File Dimensione Formato  
23.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 145.95 kB
Formato Adobe PDF
145.95 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
nihms800968.pdf

accesso aperto

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 361.35 kB
Formato Adobe PDF
361.35 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/646932
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 48
  • ???jsp.display-item.citation.isi??? 41
social impact