Several drugs or pharmacologically active molecules such as statins, calcium antagonists, and PPAR agonists have been shown to affect macrophage functions that contribute to atherosclerosis and modulate plaque stability. For example, the modulation of matrix metalloproteinase secretion and cholesterol metabolism in macrophages may help to prevent cardiovascular disease independently of the correction of risk factors.
Modulation of macrophage function and metabolism / S. Bellosta, F. Bernini (HANDBOOK OF EXPERIMENTAL PHARMACOLOGY). - In: Atherosclerosis : diet and drugs / [a cura di] A. von Eckardstein. - Berlin : Springer, 2005. - ISBN 9783540225690. - pp. 665-695 [10.1007/3-540-27661-0_25]
Modulation of macrophage function and metabolism
S. BellostaPrimo
;
2005
Abstract
Several drugs or pharmacologically active molecules such as statins, calcium antagonists, and PPAR agonists have been shown to affect macrophage functions that contribute to atherosclerosis and modulate plaque stability. For example, the modulation of matrix metalloproteinase secretion and cholesterol metabolism in macrophages may help to prevent cardiovascular disease independently of the correction of risk factors.
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