5'-Deoxy-5-fluorouridine (doxifluridine) is a prodrug of 5-fluorouracil (5FU) selectively activated by tumor cells. Since in clinical studies the side effects of doxifluridine differed after intravenous (i.v.) or oral administration, and oral route was the most promising in preclinical studies with murine models, in this study the drug was tested orally against a panel of human colorectal tumor xenografts with varying degrees of sensitivity to 5FU. Doxifluridine efficacy was comparable to that of 5FU when it was delivered according to a weekly schedule, but it was statistically higher when it was delivered more frequently. Impressive turner inhibition (between. 90 and 97%) was achieved in 4 out of 5 tumor lines after treatments delivered twice a week or daily 5 times a week. No difference in 5FU activity was observed between weekly and biweekly treatments, or between oral and i.v. injections. Moreover, in one tumor line in which different dosages of doxifluridine were investigated a mal ked antitumor effect was obtained with a wide range of tolerated doses (4000-8000 mg/kg). Overall, these data indicated that doxifluridine is well tolerated when given orally and f equently. Using an adequate schedule, the prodrug has a better therapeutic efficacy against a variety of human colon cancel models than 5FU.
Remarkable antitumor activity of 5'-deoxy-5-fluorouridine in human colorectal tumor xenografts / M. De Cesare, G. Pratesi, F. De Braud, F. Zunino, C. Stampino. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 14:2(1994), pp. 549-554.
|Titolo:||Remarkable antitumor activity of 5'-deoxy-5-fluorouridine in human colorectal tumor xenografts|
|Parole Chiave:||doxifluridine; 5-fluorouracil; colorectal cancer; tumor xenografts; nude mice|
|Settore Scientifico Disciplinare:||Settore MED/06 - Oncologia Medica|
|Data di pubblicazione:||1994|
|Appare nelle tipologie:||01 - Articolo su periodico|