A total of 51 patients with large, primary, high-grade soft-tissue sarcomas of the extremities were treated at our institute with two preoperative and three postoperative cycles of doxorubicin plus ifosfamide/mesna. Preoperative doxorubicin was given intra-arterially for lesions of the lower extremities. Of 47 evaluable patients, 22 (47%) showed clinical responses and 21 (45%), pathologic responses. Clinical and pathologic responses, however, were not necessarily coincident in the same patient. Conservative limb-sparing surgery was performed in 41 cases (87%), and in 4 cases amputation was avoided as a result of the local improvement induced by chemotherapy. Local recurrence occurred in 12 cases (25%), 3 of which required further amputation. Although the follow-up period was only 28 months, the 4-year actuarial survival was 91% and the 4-year metastasis-free value was 69%. An evident difference existed between patients who showed a documented clinical response to chemotherapy and those who did not, the 4-year metastasis-free value being 85% and 59% (P = 0.1), respectively. Adjuvant preoperative chemotherapy may allow for limb-salvage surgical procedures in selected cases.
Preoperative doxorubicin plus ifosfamide in primary soft-tissue sarcomas of the extremities / A. Azzarelli, V. Quagliuolo, P. Casali, S. Fissi, F. Montalto, A. Santoro. - In: CANCER CHEMOTHERAPY AND PHARMACOLOGY. - ISSN 0344-5704. - 31:suppl. 2(1993), pp. S210-s212. ((Intervento presentato al convegno Satellite symp on ifosfamide in the treatment of sarcomas, at the 6th European conf on clinical oncology and cancer nursing tenutosi a Firenze nel 1991.
|Titolo:||Preoperative doxorubicin plus ifosfamide in primary soft-tissue sarcomas of the extremities|
|Parole Chiave:||Soft-tissue sarcoma; preoperative chemotherapy; surgery|
|Settore Scientifico Disciplinare:||Settore MED/06 - Oncologia Medica|
|Data di pubblicazione:||1993|
|Appare nelle tipologie:||01 - Articolo su periodico|