Objectives: To identify the clinical factors predicting a good clinical response to anti-TNF therapy in rheumatoid arthritis (RA) patients entered in the LORHEN registry after 5. years of treatment with anti-TNF agents and divided into two groups on the basis of their baseline DAS28scores (moderate. >. 3.2-5.1 [MDA] and high. >. 5.1 [HDA]). Methods: Disease activity at baseline and after 12. months was assessed using the DAS28, and response was evaluated using the EULAR improvement criteria. Results: The study involved 1300patients with established RA: 975 with HDA and 325with MDA. After a mean 36-month, 29.6% of the patients had a DAS28 score of less or equal to 2.6 (HDA 25.8% vs. MDA 43.0%; P<. 0.001) and were considered to be in remission. A higher probability of a good EULAR response in patients with HDA was associated with male gender (F vs. M-OR 0.45, 95% CI 0.26-0.78; P: 0.004), lower age at the start of treatment (OR 0.98, 95% CI 0.96-0.99; P: 0.002), the absence of comorbidities (OR 0.18, 95% CI 0.06-0.52; P: 0.002) or no previous use of corticosteroids (OR 1.92, 95% CI 1.14-3.22; P: 0.015) and the use of adalimumab vs. infliximab (OR 2.21, 95% CI 1.37-3.57; P 0.001); in patients with MDA, the probability of a good EULAR response was associated with male gender (F vs. M-OR 0.39, 95% CI 0.17-0.90; P: 0.027). Conclusions: With the exception of male gender, the factors predicting a good EULAR response are different in patients with MDA and those with HDA.
Predictors of response to anti-TNF therapy in RA patients with moderate or high DAS28scores / F. Atzeni, S. Bongiovanni, A. Marchesoni, M. Filippini, R. Caporali, R. Gorla, L. Cavagna, E.G. Favalli, F. Saccardo, P. Sarzi-Puttini. - In: JOINT BONE SPINE. - ISSN 1297-319X. - 81:1(2014 Jan), pp. 37-40.
|Titolo:||Predictors of response to anti-TNF therapy in RA patients with moderate or high DAS28scores|
|Parole Chiave:||Anti-TNF; DAS28 scores; High and moderate disease activity; Predictive factors; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Prognosis; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Registries; Rheumatology; Medicine (all)|
|Settore Scientifico Disciplinare:||Settore MED/16 - Reumatologia|
|Data di pubblicazione:||gen-2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jbspin.2013.04.005|
|Appare nelle tipologie:||01 - Articolo su periodico|