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EnglishDespite the demonstrated benefits of statins and injectable biologics, there is a need for new and safe oral agents for addressing classical lipid targets, low-density lipoprotein cholesterol (LDL-C), triglycerides and high-density lipoprotein cholesterol (HDL-C). LDL-C is unquestionably causal in the development of atherogenesis and atherosclerotic cardiovascular disease, but new options are required to address triglyceride-rich lipoproteins and lipoprotein(a). For hypercholesterolaemia, pitavastatin provides a very low dose and potent statin that does not adversely affect glucose metabolism; bempedoic acid acts at a biochemical step preceding hydroxymethylglutaryl-CoA reductase and is not associated with muscular side effects. For hypertriglyceridaemia, pemafibrate displays a unique and selective agonist activity on peroxisomal proliferator activated receptor-α that does not elevate homocysteine or creatinine. Although omega-3 fatty acids supplementation is not effective in secondary prevention, high dose eicosapentaenoic ethyl ester can lead to a remarkable fall in first and recurrent events in high risk patients with hypertriglyceridaemia/low HDL-C. Gemcabene, a dicarboxylic acid regulating apolipoprotein B-100, is effective in reducing both cholesterol and triglycerides. Among cholesteryl ester transfer protein antagonists that elevate HDL-C, only anacetrapib reduces cardiovascular events. Probucol stimulates reverse cholesteryl ester transport, lowers LDL-C stabilizing plaques and may lower incidence of cardiovascular events. These agents, which act through novel mechanisms, afford good and potentially safe treatment choices that may increase adherence and the attainment of therapeutic targets.
Recent advances in synthetic pharmacotherapies for dyslipidaemias / C.R. Sirtori, S. Yamashita, M.F. Greco, A. Corsini, G. F Watts, M. Ruscica. - In: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. - ISSN 2047-4873. - (2019). [Epub ahead of print]
| Titolo: | Recent advances in synthetic pharmacotherapies for dyslipidaemias | |
| Autori: | RUSCICA, MASSIMILIANO [Writing – Review & Editing] | |
| Parole Chiave: | bempedoic acid; gemcabene; high-dose eicosapentaenoic acid; pitavastatin; probucol | |
| Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale Settore BIO/14 - Farmacologia | |
| Data di pubblicazione: | 2019 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Data ahead of print / Data di stampa: | 6-mag-2019 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1177/2047487319845314 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| CPR845314.pdf | Post-print, accepted manuscript ecc. (versione accettata dall'editore) | Open Access Visualizza/Apri | ||
| 2047487319845314.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
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