Most patients with squamous cell carcinomas of the head and neck (SCCHN) present with incurable or recurrent disease, and many who are cured acquire unacceptable functional and cosmetic deficits as a consequence of conventional therapy [1,2]. Effective cytotoxic treatment regimens may eventually cure patients in advanced stages as well as prevent recurrences and reduce the undesirable consequences of conventional therapy in patients with earlier stages [3–5]. Overall and complete response (CR) rates in the range of 80–90% and 35–54% respectively, have been reported in advanced tumors [1]. CR rates above 80% have been described recently in pilot trials using intensive chemotherapy or concurrent chemo-radiotherapy [6–7]. Patients achieving clinical CR demonstrate survival advantages [1–5] which are particularly evident when therapy results in the eradication of microscopic disease [8]. Nevertheless, following initial treatment, 50% of the patients achieve less than a CR, and 50% of the CRs are associated with residual microscopic disease.
Methodology and Clinical Applications of Cellular DNA Content Parameters Determined by Flow Cytometry in Squamous Celi Cancers of the Head and Neck / J.F. Ensley, L. Maciorowski, H. Pietraszkiewicz, F. de Braud, W. and Sakr (CANCER TREATMENT AND RESEARCH). - In: Carcinomas of Head and Neck : Evaluation and managment / [a cura di] C. Jacobs. - Boston : Kluvert Academic Publishers,, 1990. - ISBN 9781461288060. - pp. 225-242
Titolo: | Methodology and Clinical Applications of Cellular DNA Content Parameters Determined by Flow Cytometry in Squamous Celi Cancers of the Head and Neck |
Autori: | |
Parole Chiave: | Squamous Cell Cancer; Aneuploid Tumor; Diploid Tumor; Percent Label Mitosis; Proc AACR |
Settore Scientifico Disciplinare: | Settore MED/06 - Oncologia Medica |
Data di pubblicazione: | 1990 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/978-1-4613-1499-8_14 |
Tipologia: | Book Part (author) |
Appare nelle tipologie: | 03 - Contributo in volume |