Monoclonal antibodies (mAbs) against human monocytoid cells are “relatively specific” (1,3) and spurious cross-reactivity with other cell types can be detected “in vitro” in experimental models (3). Thus, instead of a single mAb it is customary to identify a specific cell type by the use of a panel of mAbs. Among the system of mononuclear phagocytes (MPS) (2,4), however, some cell types show characteristic histological distribution in the various organs and the specificity of a mAb for each single cell type is relatively simple to assess by immunohistochemical methods. In order to test the reactivity of the anti-myeloid stem cell mAbs of the Workshop, various tissues, including most of the cell types belonging in the mononuclear phagocytic system, were studied.* In addition GR positivity was easily detected in the tissues studied.

Immunohistochemical reactivity of anti-myeloid/stem celi work-shop monoclonal antibodies in thymus, lymph node, lung, liver and normal skin / E. Berti, M.G. Paindelli, C. Parravicini, G. Cattoretti, D. Delia, F. de Braud - In: Leukocyte Typing II. 3. Human Myeloid and Hematopoietic Cells / [a cura di] E.L. Reinherz, L.M. Nadler, B.F. Haynes, I.D. Bernstein. - [s.l] : Springer-Verlag, 1986. - ISBN 9781461293293. - pp. 237-247 [10.1007/978-1-4612-4850-7_19]

Immunohistochemical reactivity of anti-myeloid/stem celi work-shop monoclonal antibodies in thymus, lymph node, lung, liver and normal skin

E. Berti;F. de Braud
1986

Abstract

Monoclonal antibodies (mAbs) against human monocytoid cells are “relatively specific” (1,3) and spurious cross-reactivity with other cell types can be detected “in vitro” in experimental models (3). Thus, instead of a single mAb it is customary to identify a specific cell type by the use of a panel of mAbs. Among the system of mononuclear phagocytes (MPS) (2,4), however, some cell types show characteristic histological distribution in the various organs and the specificity of a mAb for each single cell type is relatively simple to assess by immunohistochemical methods. In order to test the reactivity of the anti-myeloid stem cell mAbs of the Workshop, various tissues, including most of the cell types belonging in the mononuclear phagocytic system, were studied.* In addition GR positivity was easily detected in the tissues studied.
Mononuclear Phagocyte; Immunoelectron Microscopy; Immunohistochemical Reactivity; Eccrine Sweat Gland; Single Cell Type
Settore MED/06 - Oncologia Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/641836
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