A global scientific strategy to cure hepatitis B

Revill, P.A.; Chisari, F.V.; Block, J.M.; Dandri, M.; Gehring, A.J.; Guo, H.; Jianming, H.; Kramvis, A.; Lampertico, P.; Janssen, H.L.A.; Levrero, M.; Wenhui, L.; Liang, T.J.; Lim, S.; Fengmin, L.; Penicaud, M.C.; Tavis, J.E.; Thimme, R.; Zoulim, F.; Arbuthnot, P.; Boonstra, P.A.; Chang, K.; Chen, P.; Glebe, D.; Guidotti, L.G.; Fellay, J.; Ferrari, C.; Jansen, L.; Lau, D.T.Y.; Lok, A.S.; Maini, M.K.; Mason, W.; Matthews, G.; Paraskevis, D.; Petersen, J.; Rehermann, B.; Shin, E.; Thompson, A.; van Bömmel, F.; Wang, F.; Watashi, K.; Yang, H.; Yuan, Z.; Yuen, M.; Block, T.; Miller, V.; Protzer, U.; Bréchot, C.; Locarnini, S.; Peters, M.G.; Schinazi, R.F.

doi:10.1016/S2468-1253(19)30119-0

Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE-HBV) is a coalition of experts dedicated to accelerating the discovery of a cure for chronic hepatitis B. Following extensive consultation with more than 50 scientists from across the globe, as well as key stakeholders including people affected by HBV, we have identified gaps in our current knowledge and new strategies and tools that are required to achieve HBV cure. We believe that research must focus on the discovery of interventional strategies that will permanently reduce the number of productively infected cells or permanently silence the covalently closed circular DNA in those cells, and that will stimulate HBV-specific host immune responses which mimic spontaneous resolution of HBV infection. There is also a pressing need for the establishment of repositories of standardised HBV reagents and protocols that can be accessed by all HBV researchers throughout the world. The HBV cure research agenda outlined in this position paper will contribute markedly to the goal of eliminating HBV infection worldwide.

A global scientific strategy to cure hepatitis B / P.A. Revill, F.V. Chisari, J.M. Block, M. Dandri, A.J. Gehring, H. Guo, J. Hu, A. Kramvis, P. Lampertico, H.L.A. Janssen, M. Levrero, W. Li, T.J. Liang, S. Lim, F. Lu, M.C. Penicaud, J.E. Tavis, R. Thimme, F. Zoulim, P. Arbuthnot, P.A. Boonstra, K. Chang, P. Chen, D. Glebe, L.G. Guidotti, J. Fellay, C. Ferrari, L. Jansen, D.T.Y. Lau, A.S. Lok, M.K. Maini, W. Mason, G. Matthews, D. Paraskevis, J. Petersen, B. Rehermann, E. Shin, A. Thompson, F. van Bömmel, F. Wang, K. Watashi, H. Yang, Z. Yuan, M. Yuen, T. Block, V. Miller, U. Protzer, C. Bréchot, S. Locarnini, M.G. Peters, R.F. Schinazi. - In: THE LANCET. GASTROENTEROLOGY & HEPATOLOGY. - ISSN 2468-1253. - 4:7(2019 Jul), pp. 545-558. [Epub ahead of print]

Titolo:	A global scientific strategy to cure hepatitis B
Autori:	Revill, Peter A Chisari, Francis V Block, Joan M Dandri, Maura Gehring, Adam J Guo, Haitao Hu, Jianming Kramvis, Anna LAMPERTICO, PIETRO Janssen, Harry L A Levrero, Massimo Li, Wenhui Liang, T Jake Lim, Seng-Gee Lu, Fengmin Penicaud, M Capucine Tavis, John E Thimme, Robert Zoulim, Fabien Arbuthnot, Patrick Boonstra, P Andre Chang, Kyong-Mi Chen, Per-Jei Glebe, Dieter Guidotti, Luca G. Fellay, Jacques Ferrari, Carlo Jansen, Louis Lau, Daryl T Y Lok, Anna S Maini, Mala K Mason, William Matthews, Gail Paraskevis, Dimitrios Petersen, Jörg Rehermann, Barbara Shin, Eui-Cheol Thompson, Alex van Bömmel, Florian Wang, Fu-Sheng Watashi, Koichi Yang, Hung-Chih Yuan, Zhenghong Yuen, Man-Fung Block, Timothy Miller, Veronica Protzer, Ulrike Bréchot, Christian Locarnini, Stephen Peters, Marion G Schinazi, Raymond F mostra contributor esterni nascondi contributor esterni
Settore Scientifico Disciplinare:	Settore MED/12 - Gastroenterologia
Data di pubblicazione:	lug-2019
Rivista:	THE LANCET. GASTROENTEROLOGY & HEPATOLOGY
Tipologia:	Article (author)
Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/S2468-1253(19)30119-0
Appare nelle tipologie:	01 - Articolo su periodico

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