Starting from the pioneering discovery of picoplatin and phenanthriplatin, many efforts were realized by different research groups in the synthesis of different platinum(II) complexes, bearing a N-heterocycle moiety active as anticancer agents in different types of solid tumors. This review deals in particular with both the bifunctional and monofunctional platinum drugs, not only in dichloride platinum(II) complexes, but also in recent advances in modern platinum structures, i.e. cationic ones. Both the in vitro and in vivo studies of these anticancer agents are taken into account, with a special consideration for aggressive and orphan in treatment tumors.

Anticancer platinum(II) complexes bearing N-heterocycle rings / G. Facchetti, I. Rimoldi. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 29:11(2019 Jun), pp. 1257-1263.

Anticancer platinum(II) complexes bearing N-heterocycle rings

G. Facchetti
Primo
;
I. Rimoldi
Ultimo
2019-06

Abstract

Starting from the pioneering discovery of picoplatin and phenanthriplatin, many efforts were realized by different research groups in the synthesis of different platinum(II) complexes, bearing a N-heterocycle moiety active as anticancer agents in different types of solid tumors. This review deals in particular with both the bifunctional and monofunctional platinum drugs, not only in dichloride platinum(II) complexes, but also in recent advances in modern platinum structures, i.e. cationic ones. Both the in vitro and in vivo studies of these anticancer agents are taken into account, with a special consideration for aggressive and orphan in treatment tumors.
Bifunctional complex; Cancer therapy; Monofunctional complex; Platinum(II) complex; Tumor cell lines; Biochemistry; Molecular Medicine; Molecular Biology; Drug Discovery; 3003; Pharmaceutical Science; Clinical Biochemistry; Organic Chemistry
Settore CHIM/03 - Chimica Generale e Inorganica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/640955
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