Objective. To determine the serologic specificity of acid eluates from tissues of a child who died with congenital complete heart block (CCHB). Methods. Tissues were extracted, acid eluted, and the IgG and antibody titers determined on the eluates by enzyme-linked immunosorbent assay. Results. Antibodies to native 60-kd and denatured 52-kd Ro/SS-A were found to be enriched only in the heart eluate, and not in the eluates from brain, kidney, and skin. Conclusion. These findings indicate a major role for anti-native 60-kd Ro/SS-A in the immunopathogenesis of CCHB.
Concentration of autoantibodies to native 60‐kd ro/ss‐a and denatured 52‐kd ro/ss‐a in eluates from the heart of a child who died with congenital complete heart block / M. Reichlin, A. Brucato, M.B. Frank, P.J. Maddison, V.R. Mccubbin, M. Wolfson-Reichlin, L.A. Lee. - In: ARTHRITIS AND RHEUMATISM. - ISSN 0004-3591. - 37:11(1994), pp. 1698-1703.
|Titolo:||Concentration of autoantibodies to native 60‐kd ro/ss‐a and denatured 52‐kd ro/ss‐a in eluates from the heart of a child who died with congenital complete heart block|
|Parole Chiave:||Neonatal lupus-erythematosus; connective-tissue disease; RO SS-A; sjogrens syndrome; antibodies; antigen; immunoglobulin; deposition; mothers; risk|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||1994|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/art.1780371120|
|Appare nelle tipologie:||01 - Articolo su periodico|