Pregnancies in women with autoantibodies against Ro/SSA and/or La/SSB may be associated with permanent and treatment resistant fetal atrioventricular (AV) block. We describe a patient with primary Sjogren's syndrome and anti-Re (60 kDa and 52 kDa) and anti-La autoantibodies, in whom fetal bradycardia with second-degree AV block was detected at 19 + 0 weeks of gestation. Maternal treatment with dexamethasone (4 mg/day po) was started 2 days later. The baby's heart rate improved gradually, returning to normal after about 6 weeks of treatment. Our case illustrates the importance of close monitoring of the fetal heart rate in risk-pregnancies from about week 16 of gestation and initiation of dexamethasone treatment without delay when a block is detect

Primary Sjögren’s Syndrome : Treatment of Fetal Incomplete Atrioventricular Block with Dexamethasone / E. Theander, A. Brucato, S. Gudmundsson, S. Salomonsson, M. Wahren-Herlenius, R. Manthorpe. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - 28:2(2001), pp. 373-376.

Primary Sjögren’s Syndrome : Treatment of Fetal Incomplete Atrioventricular Block with Dexamethasone

A. Brucato;
2001

Abstract

Pregnancies in women with autoantibodies against Ro/SSA and/or La/SSB may be associated with permanent and treatment resistant fetal atrioventricular (AV) block. We describe a patient with primary Sjogren's syndrome and anti-Re (60 kDa and 52 kDa) and anti-La autoantibodies, in whom fetal bradycardia with second-degree AV block was detected at 19 + 0 weeks of gestation. Maternal treatment with dexamethasone (4 mg/day po) was started 2 days later. The baby's heart rate improved gradually, returning to normal after about 6 weeks of treatment. Our case illustrates the importance of close monitoring of the fetal heart rate in risk-pregnancies from about week 16 of gestation and initiation of dexamethasone treatment without delay when a block is detect
congenital heart block; La/SSB antibodies; Sjogren's syndrome; Ro/SSA antibodies; dexamethasone
Settore MED/09 - Medicina Interna
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/638682
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