Cerebral small-vessel alterations play a central role in determining lesions of subcortical structures and eventually may lead to cognitive impairment. Small-vessel diseases are classified according to the pathological viewpoint. The most important ones are the changes in small arteries and arterioles caused by prolonged hypertension. These small-vessel changes may result in ischemic damage to the brain parenchyma and blood-barrier alterations. Both mechanisms are thought to contribute to the occurrence of white-matter changes and lacunar infarcts. Modern magnetic resonance techniques such as diffusion, perfusion, and spectroscopy may allow the in vivo study of the pathophysiology of small-vessel diseases and the consequences on the brain parenchyma.
Pathophysiology of cerebral small vessels in vascular cognitive impairment / L. Pantoni, M. Simoni. - In: INTERNATIONAL PSYCHOGERIATRICS. - ISSN 1041-6102. - 15:suppl. 1(2003), pp. 59-65. ((Intervento presentato al convegno Conference on Vascular Burden of the Brain: New therapeutic Directions tenutosi a Madrid nel 2001.
Pathophysiology of cerebral small vessels in vascular cognitive impairment
L. Pantoni
;
2003
Abstract
Cerebral small-vessel alterations play a central role in determining lesions of subcortical structures and eventually may lead to cognitive impairment. Small-vessel diseases are classified according to the pathological viewpoint. The most important ones are the changes in small arteries and arterioles caused by prolonged hypertension. These small-vessel changes may result in ischemic damage to the brain parenchyma and blood-barrier alterations. Both mechanisms are thought to contribute to the occurrence of white-matter changes and lacunar infarcts. Modern magnetic resonance techniques such as diffusion, perfusion, and spectroscopy may allow the in vivo study of the pathophysiology of small-vessel diseases and the consequences on the brain parenchyma.File | Dimensione | Formato | |
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