Medication related osteonecrosis of the jaw (MRONJ) is characterized by exposed necrotic bone in the maxillofacial region that persists for more than eight weeks in patients taking antiresorptive or antiangiogenic drugs for bone metastasis or osteoporosis. The management of such condition depends on several factors, among which the staging of MRONJ. Though, a specific gold standard treatment has not been established to date. The aim of this case series is to describe the outcome of surgical treatment of MRONJ with the adjunct of Platelet-rich Fibrin (PRF). Eleven patients under therapy with alendronate underwent surgical removal of necrotic bone and debridement, followed by placement of PRF membranes in the bone defect. The outcome of the surgical treatment was successful in all patients, in a follow-up range from 12 to 36 months. In the cases presented, the macroscopic evaluation showed excellent and fast soft tissue healing, with no recurrence of bone exposure and no signs of infections. PRF membranes were also effective for postsurgical pain control. The use of PRF may represent a valuable adjunct in the surgical management of MRONJ.
The use of Platelet-rich Fibrin in the management of medication-related osteonecrosis of the jaw: A case series / C. Fernando de Almeida Barros Mourão, M.D. Calasans-Maia, M. Del Fabbro, F. Le Drapper Vieira, R. Coutinho de Mello Machado, R. Capella, R.J. Miron, G. Gomes Alves. - In: JOURNAL OF STOMATOLOGY, ORAL AND MAXILLOFACIAL SURGERY. - ISSN 2468-7855. - (2019 Feb 20). [Epub ahead of print]
The use of Platelet-rich Fibrin in the management of medication-related osteonecrosis of the jaw: A case series
M. Del Fabbro;
2019
Abstract
Medication related osteonecrosis of the jaw (MRONJ) is characterized by exposed necrotic bone in the maxillofacial region that persists for more than eight weeks in patients taking antiresorptive or antiangiogenic drugs for bone metastasis or osteoporosis. The management of such condition depends on several factors, among which the staging of MRONJ. Though, a specific gold standard treatment has not been established to date. The aim of this case series is to describe the outcome of surgical treatment of MRONJ with the adjunct of Platelet-rich Fibrin (PRF). Eleven patients under therapy with alendronate underwent surgical removal of necrotic bone and debridement, followed by placement of PRF membranes in the bone defect. The outcome of the surgical treatment was successful in all patients, in a follow-up range from 12 to 36 months. In the cases presented, the macroscopic evaluation showed excellent and fast soft tissue healing, with no recurrence of bone exposure and no signs of infections. PRF membranes were also effective for postsurgical pain control. The use of PRF may represent a valuable adjunct in the surgical management of MRONJ.File | Dimensione | Formato | |
---|---|---|---|
J Stomat OMFS 2019 Mourao PRF in management MRONJ.pdf
accesso riservato
Tipologia:
Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione
469.21 kB
Formato
Adobe PDF
|
469.21 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
1-s2.0-S2468785519300552-main.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
1.16 MB
Formato
Adobe PDF
|
1.16 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.