Objective. To study anti-Ro/La-negative congenital heart block (CHB). Methods. Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods. Results. There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers. Conclusion. Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases.

Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases / A. Brucato, C. Grava, M. Bortolati, K. Ikeda, O. Milanesi, R. Cimaz, V. Ramoni, G. Vignati, S. Martinelli, Y. Sadou, A. Borghi, A. Tincani, E.K.L. Chan, A. Ruffatti. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - 36:8(2009), pp. 1744-1748.

Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases

A. Brucato;R. Cimaz;
2009

Abstract

Objective. To study anti-Ro/La-negative congenital heart block (CHB). Methods. Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods. Results. There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers. Conclusion. Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases.
Heart block; antinuclear antibodies; autoimmune diseases
Settore MED/09 - Medicina Interna
2009
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/636786
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