The treatment of pericarditis remains largely empirical owing to a relative lack of randomized, controlled trials; nevertheless, a number of observational studies and the first randomized trials are moving the management of pericardial diseases on the road to evidence-based medicine. Moreover, emerging data suggest that treatment can be tailored to the specific patient and, although the optimal length of treatment is not clearly established, some recommendations can be formulated to guide management and follow-up. Aspirin or a NSAID at medium-to-high dosages are the mainstay of treatment (e.g., aspirin 2-4 g/day, ibuprofen 1200-1800 mg/day, indomethacin 75-150 mg/day). Corticosteroid use should be restricted, and low-to-medium doses (i.e., prednisone 0.2-0.5 mg/kg/day) should be preferred. Colchicine 0.5-1.2 mg/day is effective for reducing recurrences.
Individualized therapy for pericarditis / M. Imazio, A. Brucato, R. Trinchero, D. Spodick, Y. Adler. - In: EXPERT REVIEW OF CARDIOVASCULAR THERAPY. - ISSN 1477-9072. - 7:8(2009), pp. 965-975. [10.1586/erc.09.82]
Individualized therapy for pericarditis
A. Brucato;
2009
Abstract
The treatment of pericarditis remains largely empirical owing to a relative lack of randomized, controlled trials; nevertheless, a number of observational studies and the first randomized trials are moving the management of pericardial diseases on the road to evidence-based medicine. Moreover, emerging data suggest that treatment can be tailored to the specific patient and, although the optimal length of treatment is not clearly established, some recommendations can be formulated to guide management and follow-up. Aspirin or a NSAID at medium-to-high dosages are the mainstay of treatment (e.g., aspirin 2-4 g/day, ibuprofen 1200-1800 mg/day, indomethacin 75-150 mg/day). Corticosteroid use should be restricted, and low-to-medium doses (i.e., prednisone 0.2-0.5 mg/kg/day) should be preferred. Colchicine 0.5-1.2 mg/day is effective for reducing recurrences.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.