The association between minor mutations in human immunodeficiency virus (HIV) protease at baseline and development of common primary mutation 90M at virological failure (conferring some resistance to all protease inhibitors [PIs]) was evaluated in 93 previously drug-naive patients experiencing failure of their first PI-based antiretroviral regimens. In logistic regression analysis, the probability of accumulating a new 90M mutation at virological failure was associated with the presence at baseline of minor mutation 361 (naturally occurring in ∼25% of HIV clade B and in >80% of HIV non-clade-B viruses) (adjusted odds ratio, 13.5 [95% confidence interval, 1.89-95.6]; P = .009) and, possibly, of 10I/V. This suggests a potential role for the presence of 361 at baseline in predicting the appearance of 90M at virological failure.
|Titolo:||Minor Mutations in HIV-Protease at Baseline and Appearance of Primary Mutation 90M in Patients Failing Their First Protease-Inhibitor Antiretroviral Regimens|
BALOTTA, CLAUDIA (Penultimo)
D'ARMINIO MONFORTE, ANTONELLA (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||2004|
|Digital Object Identifier (DOI):||10.1086/386307|
|Appare nelle tipologie:||01 - Articolo su periodico|