Using a commercial ELISA assay, we evaluated circulating VEGF and bFGF levels in 203 consecutive patients with solid tumors, and sought a correlation between them and with the grade of anemia. Serum VEGF values were within the normal range in 128 patients (63.05%), with a mean value of 675.04 pg/ml (median, 571.00; range, 0-2796.54). The analysis of VEGF values per tumor group did not provide any statistically significant difference. Regarding bFGF, 143 patients (70.44%) had measurable, and thus abnormal, bFGF values. Overall, mean bFGF serum value was 57.14 pg/ml (median, 8.30; range, 0-4334.71), with the highest bFGF levels found in breast carcinoma patients. As expected, a large number of our patients was fairly anemic, mean hemoglobin level being 11.47 g/dl (median, 11.30; range, 7.1-19.20), the lowest titers being observed in prostate carcinoma patients. No statistically significant correlation was found between serum VEGF and hemoglobin values (r=0.004) but a significant negative correlation was seen between serum bFGF and hemoglobin (r=-0.22, p<0.05). Considering the different tumor groups, a statistically significant negative correlation between bFGF and hemoglobin becomes even more apparent in the subgroup of renal carcinoma patients (r=-0.55, p<0.05). In conclusion, our results demonstrate that there is a statistically significant correlation between systemic hypoxia (evaluated in terms of hemoglobin levels) and circulating bFGF values, but not VEGF; this correlation may lead to therapeutic interventions.
Pro-neoangiogenic cytokines (VEGF and bFGF) and anemia in solid tumor patients / C. Porta, I. Imarisio, M. De Amici, L. Bonomi, C. Paglino, E. Biscaldi, M. Zimatore, A. Sartore-Bianchi, M. Danova, R. Moratti, A. Riccardi. - In: ONCOLOGY REPORTS. - ISSN 1021-335X. - 13:4(2005 Apr), pp. 689-695.
|Titolo:||Pro-neoangiogenic cytokines (VEGF and bFGF) and anemia in solid tumor patients|
|Parole Chiave:||VEGF; bFGF; anemia; cancer|
|Settore Scientifico Disciplinare:||Settore MED/06 - Oncologia Medica|
|Data di pubblicazione:||apr-2005|
|Appare nelle tipologie:||01 - Articolo su periodico|