Due to the frequent use of intrapleural interleukin-2 (IL-2) to treat pleural effusions from malignant mesothelioma (MMe), we measured nitric oxide (NO) end product nitrite (NO(2)(-)) in pleural effusions of 12 MMe patients with chronic or chronic-relapsing pleurisy. Through high performance liquid chromatography analysis, NO(2)(-) was found in the initial pleural fluid sample of all patients (156.25 pmol ml(-1)), and increased significantly following IL-2 intrapleural instillation, both at 24 (589.91 pmol ml(-1), P < or = 0.0005) and 48 h (756 pmol ml(-1), P< or = 0.0005). Even though it is difficult to argue if the large amounts of NO end product NO(2)(-) we observed is produced by IL-2-stimulated and recruited immune cells, by MMe cells themselves, or by both, it is possible that NO could contribute to the complex antitumor activity of IL-2.
Intrapleural interleukin-2 induces nitric oxide production in pleural effusions from malignant mesothelioma: a possible mechanism of interleukin-2-mediated cytotoxicity? / C. Porta, V. Rizzo, M. Zimatore, A. Sartore-Bianchi, M. Danova, L. Mutti. - In: LUNG CANCER. - ISSN 0169-5002. - 38:2(2002 Nov), pp. 159-162.
|Titolo:||Intrapleural interleukin-2 induces nitric oxide production in pleural effusions from malignant mesothelioma: a possible mechanism of interleukin-2-mediated cytotoxicity?|
|Parole Chiave:||intrapleural IL-2; malignant mesothelioma; nitric oxide; cytotoxicity|
|Settore Scientifico Disciplinare:||Settore MED/06 - Oncologia Medica|
|Data di pubblicazione:||nov-2002|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0169-5002(02)00187-3|
|Appare nelle tipologie:||01 - Articolo su periodico|