Background: Gastrointestinal basidiobolomycosis (GIB) is a rare mycosis affecting almost exclusively immunocompetent subjects. Methods: We describe a case of GIB caused by Basidiobolus ranarum in a 25-year-old Italian immunocompetent man resident in Ireland who presented a 2-month history of epigastric pain. Suspecting colon cancer he underwent a right hemicolectomy subsequently leading to a diagnosis of GIB by means of molecular biology. After surgery a 9-month therapy with itraconazole was employed with a good outcome. A review of medical literature regarding GIB cases published in the period 1964–2017 is presented. Results: One-hundred and two cases of GIB were included in this analysis. The disease was observed predominantly in male gender (74.5%) and children (41.2%). Abdominal pain was the single most common complaint (86.3%) followed by fever (40.2%) and evidence of an abdominal mass (30.4%). Peripheral blood eosinophilia was detected in 85.7% of cases. Most of the patients were diagnosed in Saudi Arabia (37.2%) followed by USA (21.6%) and Iran (20.6%). Surgery plus antifungal therapy was employed in the majority of patients (77.5%). An unfavourable outcome was documented globally in 18.6% of patients. Conclusions: GIB seems to be an emerging intestinal mycosis among immunocompetent patients living in the Middle East and Arizona.
Gastrointestinal basidiobolomycosis: an emerging mycosis difficult to diagnose but curable: Case report and review of the literature / M.D. Pezzani, V. Di Cristo, C. Parravicini, A. Sonzogni, C. Tonello, M. Franzetti, S. Sollima, M. Corbellino, M. Galli, L. Milazzo, S. Antinori. - In: TRAVEL MEDICINE AND INFECTIOUS DISEASE. - ISSN 1477-8939. - (2019 Jan 17). [Epub ahead of print]
Titolo: | Gastrointestinal basidiobolomycosis: an emerging mycosis difficult to diagnose but curable: Case report and review of the literature |
Autori: | PEZZANI, MARIA DILETTA (Co-primo) DI CRISTO, VALENTINA (Co-primo) |
Settore Scientifico Disciplinare: | Settore MED/17 - Malattie Infettive |
Data di pubblicazione: | 17-gen-2019 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.tmaid.2019.01.013 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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