Gastrointestinal basidiobolomycosis: an emerging mycosis difficult to diagnose but curable: Case report and review of the literature

Pezzani, M.D.; Di Cristo, V.; Parravicini, C.; Sonzogni, A.; Tonello, C.; Franzetti, M.; Sollima, S.; Corbellino, M.; Galli, M.; Milazzo, L.; Antinori, S.

doi:10.1016/j.tmaid.2019.01.013

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Background: Gastrointestinal basidiobolomycosis (GIB) is a rare mycosis affecting almost exclusively immunocompetent subjects. Methods: We describe a case of GIB caused by Basidiobolus ranarum in a 25-year-old Italian immunocompetent man resident in Ireland who presented a 2-month history of epigastric pain. Suspecting colon cancer he underwent a right hemicolectomy subsequently leading to a diagnosis of GIB by means of molecular biology. After surgery a 9-month therapy with itraconazole was employed with a good outcome. A review of medical literature regarding GIB cases published in the period 1964–2017 is presented. Results: One-hundred and two cases of GIB were included in this analysis. The disease was observed predominantly in male gender (74.5%) and children (41.2%). Abdominal pain was the single most common complaint (86.3%) followed by fever (40.2%) and evidence of an abdominal mass (30.4%). Peripheral blood eosinophilia was detected in 85.7% of cases. Most of the patients were diagnosed in Saudi Arabia (37.2%) followed by USA (21.6%) and Iran (20.6%). Surgery plus antifungal therapy was employed in the majority of patients (77.5%). An unfavourable outcome was documented globally in 18.6% of patients. Conclusions: GIB seems to be an emerging intestinal mycosis among immunocompetent patients living in the Middle East and Arizona.

Gastrointestinal basidiobolomycosis: an emerging mycosis difficult to diagnose but curable: Case report and review of the literature / M.D. Pezzani, V. Di Cristo, C. Parravicini, A. Sonzogni, C. Tonello, M. Franzetti, S. Sollima, M. Corbellino, M. Galli, L. Milazzo, S. Antinori. - In: TRAVEL MEDICINE AND INFECTIOUS DISEASE. - ISSN 1477-8939. - (2019 Jan 17). [Epub ahead of print]

Titolo:	Gastrointestinal basidiobolomycosis: an emerging mycosis difficult to diagnose but curable: Case report and review of the literature
Autori:	PEZZANI, MARIA DILETTA (Co-primo) DI CRISTO, VALENTINA (Co-primo) C. Parravicini A. Sonzogni TONELLO, CRISTINA FRANZETTI, MARCO S. Sollima M. Corbellino GALLI, MASSIMO L. Milazzo ANTINORI, SPINELLO (Ultimo) [Writing – Review & Editing] (Corresponding) mostra contributor esterni nascondi contributor esterni
Settore Scientifico Disciplinare:	Settore MED/17 - Malattie Infettive
Data di pubblicazione:	17-gen-2019
Rivista:	TRAVEL MEDICINE AND INFECTIOUS DISEASE
Tipologia:	Article (author)
Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/j.tmaid.2019.01.013
Appare nelle tipologie:	01 - Articolo su periodico

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Utilizza questo identificativo per citare o creare un link a questo documento:
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