Acute promyelocytic leukemia (APL) is caused by chromosomal translocations that involve the retinoic acid receptor a (RAR) and several other genes to yield X-RAR fusion proteins. Unlike wild-type RARs, which require heterodimerization with the retinoid X receptor (RXR) for their function as DNA-binding transcriptional regulators, X-RAR fusion proteins bind DNA and deregulate transcription as homo-oligomers. In this issue of Cancer Cell, however, Zeisig et al. and Zhu et al. show that RXR recruitment is a critical determinant for the transforming potential of oligomeric X-RAR fusion proteins and explore the possibility for targeted interventions in APL with either RAR or RXR ligands.
Determinants of oncogenic transformation in acute promyelocytic leukemia : the hetero-union makes the force / S. Minucci, P.G. Pelicci. - In: CANCER CELL. - ISSN 1535-6108. - 12:1(2007 Jul), pp. 1-3.
Determinants of oncogenic transformation in acute promyelocytic leukemia : the hetero-union makes the force
S. MinucciPrimo
;P.G. PelicciUltimo
2007
Abstract
Acute promyelocytic leukemia (APL) is caused by chromosomal translocations that involve the retinoic acid receptor a (RAR) and several other genes to yield X-RAR fusion proteins. Unlike wild-type RARs, which require heterodimerization with the retinoid X receptor (RXR) for their function as DNA-binding transcriptional regulators, X-RAR fusion proteins bind DNA and deregulate transcription as homo-oligomers. In this issue of Cancer Cell, however, Zeisig et al. and Zhu et al. show that RXR recruitment is a critical determinant for the transforming potential of oligomeric X-RAR fusion proteins and explore the possibility for targeted interventions in APL with either RAR or RXR ligands.Pubblicazioni consigliate
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