Background: Older adults dialysis patients represent the frailest subgroup of the End Stage Renal Disease (ESRD) population and physical exercise program may mitigate the age-related decline in muscle mass and function. Methods: Dialysis patients of the EXCITE trial aged > 65 years (n = 115, active arm, n = 53; control arm, n = 62) were submitted in random order to a home based, low intensity physical exercise program. At baseline and 6 months after exercise training 6-min walking distance (6MWD) and 5-time sit-to-stand test (5STS) were performed, and quality of life (QoL) was tested. Results: The training program improved both the 6MWD (6-months: 327 ± 86 m versus baseline: 294 ± 74 m; P < 0.001) and the 5STS time (6-months: 19.8 ± 5.6 s versus baseline: 22.5 ± 5.1 s; P < 0.001) in the exercise group whereas they did not change in the control group (P = 0.98 and 0.25, respectively). The between-arms differences (6 months-baseline) in the 6MWD (+ 34.0 m, 95% CI: 14.4 to 53.5 m) and in the 5STS time changes (- 1.9 s, 95% CI: -3.6 to - 0.3 s) were both statistically significant (P = 0.001 and P = 0.024, respectively). The cognitive function dimension of QoL significantly reduced in the control arm (P = 0.04) while it remained unchanged in the active arm (P = 0.78) (between groups difference P = 0.05). No patient died during the trial and the training program was well tolerated. Conclusions: This secondary analysis of the EXCITE trial shows that a home-based, exercise program improves physical performance and is well tolerated in elderly ESRD patients. Trial registration: The trial was registered in ClinicalTrials.Gov (Clinicaltrials.gov identifier: NCT01255969) on December 8, 2010.
Effect of a home based, low intensity, physical exercise program in older adults dialysis patients: A secondary analysis of the EXCITE trial / R. Baggetta, G. D'Arrigo, C. Torino, S.A. Elhafeez, F. Manfredini, F. Mallamaci, C. Zoccali, G. Tripepi, D. Bolignano, N. Lamberti, S. Bertoli, D. Ciurlino, L. Rocca-Rey, A. Barillà, Y. Battaglia, R.M. Rapanà, A. Zuccalà, G. Bonanno, P. Fatuzzo, F. Rapisarda, S. Rastelli, F. Fabrizi, P. Messa, L. De Paola, L. Lombardi, A. Cupisti, G. Fuiano, G. Lucisano, C. Summaria, M. Felisatti, E. Pozzato, A.M. Malagoni, P. Castellino, F. Aucella, P.F. Provenzano, L. Catizone. - In: BMC GERIATRICS. - ISSN 1471-2318. - 18:1(2018 Oct 20).
|Titolo:||Effect of a home based, low intensity, physical exercise program in older adults dialysis patients: A secondary analysis of the EXCITE trial|
BERTOLI, SILVIO [Membro del Collaboration Group]
ROCCA REY, LISA ALLEGRA [Membro del Collaboration Group]
MESSA, PIERGIORGIO [Membro del Collaboration Group]
|Parole Chiave:||Dialysis patients; Physical exercise; Quality of life; Geriatrics and Gerontology;|
|Settore Scientifico Disciplinare:||Settore MED/14 - Nefrologia|
|Data di pubblicazione:||20-ott-2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1186/s12877-018-0938-5|
|Appare nelle tipologie:||01 - Articolo su periodico|
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