Cancer-associated fibroblasts (CAF) are the most abundant cells of the tumor stroma and they critically influence cancer growth through control of the surrounding tumor microenvironment (TME). CAF-orchestrated reactive stroma, composed of pro-tumorigenic cytokines and growth factors, matrix components, neovessels, and deregulated immune cells, is associated with poor prognosis in multiple carcinomas, including breast cancer. Therefore, beyond cancer cells killing, researchers are currently focusing on TME as strategy to fight breast cancer. In recent years, nanomedicine has provided a number of smart delivery systems based on active targeting of breast CAF and immune-mediated overcome of chemoresistance. Many efforts have been made both to eradicate breast CAF and to reshape their identity and function. Nano-strategies for CAF targeting profoundly contribute to enhance chemosensitivity of breast tumors, enabling access of cytotoxic T-cells and reducing immunosuppressive signals. TME rearrangement also includes reorganization of the extracellular matrix to enhance permeability to chemotherapeutics, and nano-systems for smart coupling of chemo- and immune-therapy, by increasing immunogenicity and stimulating antitumor immunity. The present paper reviews the current state-of-the-art on nano-strategies to target breast CAF and TME. Finally, we consider and discuss future translational perspectives of proposed nano-strategies for clinical application in breast cancer.
Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy / M. Truffi, S. Mazzucchelli, A. Bonizzi, L. Sorrentino, R. Allevi, R. Vanna, C. Morasso, F. Corsi. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 20:6(2019 Mar 13), pp. E1263.1-E1263.18.
|Titolo:||Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy|
TRUFFI, MARTA (Primo)
CORSI, FABIO RUGGERO MARIA (Ultimo) (Corresponding)
|Parole Chiave:||cancer-associated fibroblasts; tumor microenvironment; nanoparticles; breast cancer; antitumor efficacy|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
Settore BIO/10 - Biochimica
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
Settore BIO/13 - Biologia Applicata
|Data di pubblicazione:||13-mar-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/ijms20061263|
|Appare nelle tipologie:||01 - Articolo su periodico|