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EnglishObjectiveThe objective of this study was to investigate the effect of lower protein (LP) versus higher protein (HP) content in infant formula on body composition from 3 months to 6 years. MethodsIn a multicenter, double-blind European trial, healthy infants (N=1,090) were randomly assigned to different protein content formulas (upper [HP] and lower [LP] limits of the European Union regulations in 2001) during the first year; breastfed infants (N=588) were recruited for reference values. Weight, height, and triceps and subscapular skinfold (SF) thickness were measured repeatedly (N=650 at 6 years), and body composition was estimated (Slaughter). The 99th percentile of fat mass index reference data were used to assess excess body fat at 6 years. ResultsAt 2 and 6 years, the study observed greater sum of SFs ( 2 years: 0.5 mm, P=0.026, 6 years: 0.6 mm, P=0.045), fat mass index ( 2 years: 0.12 kg/m(2), P=0.008, 6 years: 0.15 kg/m(2), P=0.011), and fat-free mass index ( 2 years: 0.17 kg/m(2), P=0.003, 6 years: 0.18 kg/m(2), P=0.010) in the HP group compared with the LP group. At 6 years, the HP group had a twofold higher risk than the LP group for excess body fat (adjusted odds ratio: 2.13, P=0.019). ConclusionsInfant formula with HP levels induced greater fat mass in children from 2 to 6 years. Lowering the protein content of infant formula may result in a healthier body composition in early childhood.
Effect of Lower Versus Higher Protein Content in Infant Formula Through the First Year on Body Composition from 1 to 6 Years: Follow-Up of a Randomized Clinical Trial / M. Totzauer, V. Luque, J. Escribano, R. Closa-Monasterolo, E. Verduci, A. Redionigi, J. Hoyos, J. Langhendries, D. Gruszfeld, P. Socha, B. Koletzko, V. Grote. - In: OBESITY. - ISSN 1930-739X. - 26:7(2018 Jul), pp. 1203-1210.
| Titolo: | Effect of Lower Versus Higher Protein Content in Infant Formula Through the First Year on Body Composition from 1 to 6 Years: Follow-Up of a Randomized Clinical Trial | |
| Autori: | ||
| Parole Chiave: | Childhood-obesity; mass index; weight-gain; risk-factor; growth; children; association; fat; age; overweight | |
| Settore Scientifico Disciplinare: | Settore MED/38 - Pediatria Generale e Specialistica | |
| Progetto: | Long-term effects of early nutrition on later health | |
| Data di pubblicazione: | lug-2018 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/oby.22203 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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| Totzauer_et_al-2018-Obesity.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
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