Pericarditis has several different causes, however, in about 70% of paediatric patients, a specific aetiology cannot be detected and the pericarditis is considered idiopathic. Recurrences may occur in up to 15-30% of cases. The pathogenesis of recurrent disease is controversial. Infectious, autoimmune and autoinflammatory pathways have been proposed as mechanisms involved in recurrences. Therapeutic strategies are not standardised, non-steroidal anti-inflammatory drugs at high dosages being the mainstay of therapy with the possible addition of low dose colchicine to prevent recurrences. Biological agents are considered a possible new therapeutic frontiers in the care of idiopathic recurrent pericarditis.
New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children / S. Gaspari, M. Marsili, M. Imazio, A. Brucato, C. Di Blasi Lo Cuccio, F. Chiarelli, L. Breda. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 31:5(2013), pp. 788-794.
New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children
A. Brucato;
2013
Abstract
Pericarditis has several different causes, however, in about 70% of paediatric patients, a specific aetiology cannot be detected and the pericarditis is considered idiopathic. Recurrences may occur in up to 15-30% of cases. The pathogenesis of recurrent disease is controversial. Infectious, autoimmune and autoinflammatory pathways have been proposed as mechanisms involved in recurrences. Therapeutic strategies are not standardised, non-steroidal anti-inflammatory drugs at high dosages being the mainstay of therapy with the possible addition of low dose colchicine to prevent recurrences. Biological agents are considered a possible new therapeutic frontiers in the care of idiopathic recurrent pericarditis.File | Dimensione | Formato | |
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