In this work, nano-hybrid electrospun non-woven mats made of wool keratin combined with diclofenac loaded hydrotalcites (HTD) were prepared and characterized as potential drug delivery systems and scaffolds for fibroblast cell growth. Nano-hybrid electrospun non-woven mats showed a good adaptability to wet skin, effortlessly conforming to the three-dimensional topography of the tissue. Nanosized HTD exercised an overall reinforcing action on the electrospun non-woven mats since the nanohybrid samples displayed a reduced swelling ratio and a slower degradation profile compared to keratin-based nanofiber non-woven mats containing free diclofenac, without negative effects on drug release. The cell viability test indicated a decreased toxicity of the drug when loaded into nanofibers and confirmed the biocompatibility of keratin/HTD electrospun non-woven mats; moreover, a controlled diclofenac release within the first 24 hours does not compromise the fibroblast cell growth in a significant manner.
Nano-hybrid electrospun non-wovens made of wool keratin and hydrotalcites as potential bio-active wound dressing / D. Giuri, M. Barbalinardo, G. Sotgiu, R. Zamboni, M. Nocchetti, A. Donnadio, F. Corticelli, F. Valle, C.G. Gennari, F. Selmin, T. Posati, A. Aluigi. - In: NANOSCALE. - ISSN 2040-3364. - 11:13(2019 Apr 07), pp. 6422-6430.
|Titolo:||Nano-hybrid electrospun non-wovens made of wool keratin and hydrotalcites as potential bio-active wound dressing|
|Settore Scientifico Disciplinare:||Settore CHIM/09 - Farmaceutico Tecnologico Applicativo|
|Data di pubblicazione:||7-apr-2019|
|Data ahead of print / Data di stampa:||5-mar-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1039/C8NR10114K|
|Appare nelle tipologie:||01 - Articolo su periodico|