Open partial horizontal laryngectomies (OPHLs) are well-established and oncologically safe procedures for intermediate⁻advanced laryngeal cancers (LC). T⁻N categories are well-known prognosticators: herein we tested if "anterior" vs. "posterior" tumor location (as defined in respect to the paraglottic space divided according to a plane passing through the arytenoid vocal process, perpendicular to the ipsilateral thyroid lamina) may represent an additional prognostic factor. We analyzed a retrospective cohort of 85 T3⁻4a glottic LCs, treated by Type II or III OPHL (according to the European Laryngological Society classification) from 2005 to 2017 at two academic institutions. Five-year overall survival (OS), disease-specific survivals (DSS), and recurrence-free survivals (RFS) were compared according to tumor location and pT category. Anterior and posterior tumors were 43.5% and 56.5%, respectively, 78.8% of lesions were T3 and 21.2% were T4a. Five-year OS, DSS, and RFS for T3 were 74.1%, 80.5%, and 63.4%, respectively, and for T4a 71.8%, 71.8%, and 43%, respectively (p not significant). In relation to tumor location, the survival outcomes were 91%, 94.1%, and 72.6%, respectively, for anterior tumors, and 60.3%, 66.3%, and 49.1%, respectively, for posterior lesions (statistically significant differences). These data provide evidence that laryngeal compartmentalization is a valid prognosticator, even more powerful than the pT category.
Open Partial Horizontal Laryngectomies for T3⁻T4 Laryngeal Cancer : Prognostic Impact of Anterior vs. Posterior Laryngeal Compartmentalization / F. Del Bon, C. Piazza, D. Lancini, A. Paderno, P. Bosio, S. Taboni, R. Morello, N. Montalto, F. Missale, F. Incandela, F. Marchi, M. Filauro, A. Deganello, G. Peretti, P. Nicolai. - In: CANCERS. - ISSN 2072-6694. - 11:3(2019 Mar 01), pp. 289.1-289.12.
|Titolo:||Open Partial Horizontal Laryngectomies for T3⁻T4 Laryngeal Cancer : Prognostic Impact of Anterior vs. Posterior Laryngeal Compartmentalization|
|Parole Chiave:||conservative surgery; laryngeal cancer; open partial horizontal laryngectomy; paraglottic space; prognosis|
|Settore Scientifico Disciplinare:||Settore MED/31 - Otorinolaringoiatria|
|Data di pubblicazione:||1-mar-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/cancers11030289|
|Appare nelle tipologie:||01 - Articolo su periodico|